Mattes P, Peros G, Belohlavek D, Merkle N, Kilian J
Chir Forum Exp Klin Forsch. 1980:57-60.
Twenty-two severely ill patients with multiple injuries and sepsis were treated with IV pirenzepin or placebo 3 x 10 mg per day in the frame of the double-blind study. All the patients were examined three times with endoscopy during the 14-day observation period. In 100% of cases without prophylactic treatment, stress lesions were observed, 60% of these cases had bleeding. A prophylactic IV pirenzepin application had an unmistakable protective effect regarding the stress bleeding, number and degree of stress lesions.
在一项双盲研究中，22名患有多处损伤和脓毒症的重症患者接受了静脉注射哌仑西平或安慰剂治疗，剂量为每天3次，每次10毫克。在14天的观察期内，所有患者均接受了3次内窥镜检查。在100%未进行预防性治疗的病例中，观察到应激性病变，其中60%的病例出现出血。预防性静脉注射哌仑西平对应激性出血、应激性病变的数量和程度具有明显的保护作用。
