Madewall B R, Feldman B F, O'Neill S
Thromb Haemost. 1980 Aug 29;44(1):35-8.
Conventional laboratory methods were used to screen untreated tumor-bearing dogs for hemostatic abnormalities. Excluded from study were dogs with clinical evidence of bleeding. The primary site for neoplastic disease in 100 dogs studied included hemolymphatic system, skin, bone, thyroid gland, oropharynx, mammary gland, and nasal cavity. Eighty-three percent of the dogs had one or more abnormal coagulation tests. Thrombocytopenia occurred in 36 dogs and 3 had thrombocytosis. Twenty-five dogs had hypofibrinogenemia, and 25 had hyperfibrinogenemia. There were 32 dogs with prolongation of the activated partial thromboplastin time, 10 dogs with shortened prothrombin time, and 6 dogs with prolongation of the thrombin time. Sixteen dogs had positive protamine sulfate (paracoagulation) reaction, and 8% had increased plasma fibrin degradation products. The euglobulin lysis time was accelerated in 24% of the dogs, and 15% had schistocytes on blood film. These data indicate that the majority of dogs with advanced neoplasms are likely to have abnormal coagulation tests.
采用传统实验室方法对未经治疗的荷瘤犬进行止血异常筛查。有出血临床证据的犬被排除在研究之外。在研究的100只犬中，肿瘤疾病的主要发生部位包括血液淋巴系统、皮肤、骨骼、甲状腺、口咽、乳腺和鼻腔。83%的犬有一项或多项凝血试验异常。36只犬出现血小板减少，3只犬出现血小板增多。25只犬有低纤维蛋白原血症，25只犬有高纤维蛋白原血症。32只犬活化部分凝血活酶时间延长，10只犬凝血酶原时间缩短，6只犬凝血酶时间延长。16只犬硫酸鱼精蛋白（副凝血）反应阳性，8%犬血浆纤维蛋白降解产物增加。24%的犬优球蛋白溶解时间加快，15%的犬血涂片上有裂红细胞。这些数据表明，大多数晚期肿瘤犬可能有凝血试验异常。
