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对流免疫电泳显示的抗肌动蛋白抗体。与平滑肌抗体和胆小管抗体的关系。

Anti-actin antibodies revealed by counter-immunoelectrophoresis. Relation to smooth muscle antibodies and bile canalicular antibodies.

作者信息

Diederichsen H, Riisom K

出版信息

J Clin Pathol. 1980 Sep;33(9):876-9. doi: 10.1136/jcp.33.9.876.

DOI:10.1136/jcp.33.9.876
PMID:6893598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146250/
Abstract

In investigations by counter-immunoelectrophoresis, anti-actin antibodies were found in 59% of patients with chronic hepatitis and in 8% of patients with non-hepatic diseases and normal blood donors. Anti-actin antibodies were found more frequently in patients with hepatitis and IgG smooth muscle antibodies than in other groups of diseases and normal subjects with IgG smooth muscle antibodies. Anti-actin antibodies showed no correlation with bile canalicular antibodies.

摘要

在对流免疫电泳研究中,59%的慢性肝炎患者以及8%的非肝脏疾病患者和正常献血者体内发现了抗肌动蛋白抗体。与其他伴有IgG平滑肌抗体的疾病组和正常受试者相比,抗肌动蛋白抗体在伴有IgG平滑肌抗体的肝炎患者中更常见。抗肌动蛋白抗体与胆小管抗体无相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54fa/1146250/ffa670073fd0/jclinpath00469-0077-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54fa/1146250/3a8f837ae0d8/jclinpath00469-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54fa/1146250/ffa670073fd0/jclinpath00469-0077-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54fa/1146250/3a8f837ae0d8/jclinpath00469-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54fa/1146250/ffa670073fd0/jclinpath00469-0077-b.jpg

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本文引用的文献

1
G-actin:preparation by gel filtration and evidence for a double stranded structure.
Biochem Biophys Res Commun. 1963 Jul 10;12:34-8. doi: 10.1016/0006-291x(63)90409-1.
2
Studies on the isolation and molecular properties of homogeneous globular actin. Evidence for a single polypeptide chain structure.均一球形肌动蛋白的分离及分子特性研究。单条多肽链结构的证据。
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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
用蛋白A和分离的兔肝细胞膜检测慢性肝病患者血清中的肝细胞膜抗体。
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Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies.慢性肝病中针对兔胸腺可提取抗原的沉淀抗体:与抗肌动蛋白抗体的关系
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Autoantibodies and the hepatitis-associated antigen in acute infective hepatitis.急性感染性肝炎中的自身抗体与肝炎相关抗原
Br Med J. 1970 Jun 20;2(5711):693-5. doi: 10.1136/bmj.2.5711.693.
5
Rapid detection of Australia antigen by counterimmunoelectrophoresis.用对流免疫电泳法快速检测澳大利亚抗原。
J Immunol. 1970 Apr;104(4):1031-4.
6
Smooth muscle antibody in malignant disease.恶性疾病中的平滑肌抗体。
Br Med J. 1971 Nov 27;4(5786):511-3. doi: 10.1136/bmj.4.5786.511.
7
Hetero-antibody against bile canaliculi in patients with chronic, clinically active hepatitis.慢性临床活动性肝炎患者中针对胆小管的异种抗体。
Acta Med Scand. 1969 Oct;186(4):299-302. doi: 10.1111/j.0954-6820.1969.tb01480.x.
8
Immunofluorescent and enzymatic staining of bile canaliculi in the same sections of the liver.肝脏同一切片中小胆管的免疫荧光和酶染色。
Am J Clin Pathol. 1972 Aug;58(2):123-6. doi: 10.1093/ajcp/58.2.123.
9
Antibody to smooth muscle in patients with liver disease.肝病患者的平滑肌抗体。
Lancet. 1965 Oct 30;2(7418):878-9. doi: 10.1016/s0140-6736(65)92505-5.
10
Human smooth muscle autoantibody. Its identification as antiactin antibody and a study of its binding to "nonmuscular" cells.人平滑肌自身抗体。其作为抗肌动蛋白抗体的鉴定及其与“非肌肉”细胞结合的研究。
Am J Pathol. 1973 Sep;72(3):473-88.