Uretsky S H, Kennerdell J S, Gutai J P
Arch Ophthalmol. 1980 Nov;98(11):1963-4. doi: 10.1001/archopht.1980.01020040815002.
Thirty-four patients with childhood Graves' disease were examined to determine the incidence and severity of Graves' ophthalmopathy in children and adolescents. Twenty-three of the 34 patients formed a population of childhood Graves' disease unselected for ocular disease; 11 were unaffected and 12 (52.2%) had findings considered to be of mild functional importance. The remaining 11 patients were referred for evaluation because of a history of Graves' ophthalmopathy; eight (72.7%) exhibited findings of mild severity and three the more meaningful complications of ophthalmoplegia. There were no cases of dysthyroid optic neuropathy or sight-threatening corneal involvement. Both the presence of asymmetric ocular manifestations and increasing severity of disease seem to correlate with increasing age. Although ophthalmoplegia does occur infrequently, Graves' ophthalmopathy in children and adolescents seems to be a substantially more benign process than that seen in adults.
对34例儿童Graves病患者进行检查,以确定儿童和青少年Graves眼病的发病率和严重程度。34例患者中有23例构成了未因眼部疾病而被挑选的儿童Graves病群体;其中11例未受影响,12例(52.2%)有被认为具有轻度功能重要性的表现。其余11例患者因有Graves眼病病史而被转诊进行评估;8例(72.7%)表现为轻度严重程度,3例有更具意义的眼肌麻痹并发症。没有甲状腺功能异常性视神经病变或威胁视力的角膜受累病例。不对称眼部表现的出现以及疾病严重程度的增加似乎都与年龄增长相关。虽然眼肌麻痹确实很少发生,但儿童和青少年的Graves眼病似乎比成人的Graves眼病在本质上是一个更良性的过程。