Bräutigam M, Flosbach C W, Herken H
Naunyn Schmiedebergs Arch Pharmacol. 1980;315(2):177-9. doi: 10.1007/BF00499261.
Muscular rigidity was induced by reserpine (10 mg/kg) in rats and the tonic activity of the gastrocnemius muscle was recorded in the electromyogram. Systemic administration of lisuride, an ergoline, resulted in a dose-dependent depression of rigidity. To examine the spinal cord as a site of action for lisuride to depress reserpine-induced rigidity, a method for the chronic catheterization of the lumbar spinal subarachnoid space was used, which allowed the administration of drugs to reserpinized, intact rats without anaesthesia. Lisuride injected into the lumbar spinal subarachnoid space resulted in a longlasting depression of rigidity. These results suggest that the spinal cord is an important site of action of lisuride.
利血平（10毫克/千克）诱导大鼠出现肌肉强直，并在肌电图中记录腓肠肌的强直活动。麦角灵类药物利舒脲全身给药后，强直反应呈剂量依赖性降低。为了研究利舒脲降低利血平诱导的强直反应的脊髓作用位点，采用了一种慢性腰椎蛛网膜下腔置管方法，该方法可在不麻醉的情况下，向注射了利血平的完整大鼠给药。向腰椎蛛网膜下腔注射利舒脲可使强直反应长期降低。这些结果表明脊髓是利舒脲的一个重要作用位点。
