Dahlberg P A, Karlsson F A, Lundqvist G
Clin Endocrinol (Oxf). 1981 Feb;14(2):125-31. doi: 10.1111/j.1365-2265.1981.tb00607.x.
High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sparing type. No correlation between gastrin and triiodothyronine values was found. It is suggested that gastrin levels should be measured in thyrotoxic patients after treatment, and further control instituted in patients with raised gastrin levels. The relationship between gastric function, gastrin release and thyroid function seems complex. The interactions may involve both a direct effect of thyroid hormone on gastric acid production, adrenergic influences on gastrin release and linked phenomena with development of thyroid and gastric auto-immune diseases.
在连续的56例甲状腺毒症患者中，21例（38%）发现胃泌素水平升高。恢复甲状腺功能正常后，胃泌素水平通常会下降，但12例患者（21%）仍有高胃泌素血症。其中6例患者（11%）有胃酸缺乏，提示为胃窦保留型萎缩性胃炎。未发现胃泌素与三碘甲状腺原氨酸值之间存在相关性。建议对甲状腺毒症患者治疗后测定胃泌素水平，对胃泌素水平升高的患者进行进一步监测。胃功能、胃泌素释放与甲状腺功能之间的关系似乎很复杂。相互作用可能涉及甲状腺激素对胃酸分泌的直接作用、肾上腺素能对胃泌素释放的影响以及与甲状腺和胃自身免疫性疾病发展相关的现象。
