Webster J, Lewis P J, MacDermot J, Hensby C N, Kohner E M, Porta M
Prostaglandins Med. 1981 Jun;6(6):661-7. doi: 10.1016/0161-4630(81)90129-4.
Plasma levels of 6-oxo-PGF1 alpha, the hydrolysis product of prostacyclin, were significantly reduced in men with proliferative diabetic retinopathy, compared with normal controls. Male diabetics with background or no retinopathy formed an intermediate group with plasma levels of 6-oxo-PGF1 alpha lower than controls and higher than patients with proliferative retinopathy. Forearm ischaemia increased plasma levels of 6-oxo-PGF1 alpha by 30% in normal subjects. The increase occurred during arterial occlusion and was diminished by pretreatment with aspirin. The increase after ischaemia may reflect increased prostacyclin production. In diabetic patients forearm ischaemia produced an increase in plasma 6-oxo-PGF1 alpha similar to that seen in control subjects.
与正常对照组相比，患有增殖性糖尿病视网膜病变的男性体内前列环素的水解产物6-氧代前列素F1α的血浆水平显著降低。患有背景性视网膜病变或无视网膜病变的男性糖尿病患者形成一个中间组，其6-氧代前列素F1α的血浆水平低于对照组但高于增殖性视网膜病变患者。前臂缺血使正常受试者的6-氧代前列素F1α血浆水平升高30%。这种升高发生在动脉闭塞期间，并且通过阿司匹林预处理而减弱。缺血后的升高可能反映了前列环素生成增加。在糖尿病患者中，前臂缺血使血浆6-氧代前列素F1α升高，与在对照受试者中观察到的情况相似。
