Szabó I, Novák P, Drozgyik I, Bódis J
Z Geburtshilfe Perinatol. 1980 Oct;184(5):350-2.
In 8 anencephalic foetuses diagnosed by ultrasonic and x-ray examination, the authors determined the cortisol concentration of the amniotic fluid before and after intramuscular prednisolone treatment, as well as the ratio of lecithin to sphingomyeline (L/S). Compared with the data obtained in 122 normal newborn who had been born during the same pregnancy week, both the cortisol concentration and the L/S ratio was found to be significantly lower in all anencephalic foetuses. The authors found that with the anencephalic foetuses the foetal pulmonary maturity is retarded compared to the normal foetuses; antenatal treatment with glucocorticoid did not accelerate functional maturity of the foetal lung. The authors are of the opinion that an indispensable prerequisite of foetal pulmonary maturity and efficacy of the antenatal glucocorticoid treatment is an intact hypothalamic-hypophyseal adrenocortical system of the foetus.
在通过超声和X线检查诊断出的8例无脑儿胎儿中，作者测定了肌肉注射泼尼松龙治疗前后羊水的皮质醇浓度以及卵磷脂与鞘磷脂的比例（L/S）。与在同一孕周出生的122例正常新生儿所获得的数据相比，发现所有无脑儿胎儿的皮质醇浓度和L/S比例均显著降低。作者发现，与正常胎儿相比，无脑儿胎儿的肺成熟延迟；产前使用糖皮质激素治疗并未加速胎儿肺的功能成熟。作者认为，胎儿肺成熟和产前糖皮质激素治疗有效的一个必不可少的先决条件是胎儿完整的下丘脑-垂体-肾上腺皮质系统。
