Sacks L M, Schaffer D B, Anday E K, Peckham G J, Delivoria-Papadopoulos M
Pediatrics. 1981 Dec;68(6):770-4.
The relative contribution of transfusions of adult blood to the development of retrolental fibroplasia (RLF) in very low-birth-weight infants was examined. Five years of experience with the expanded use of replacement and exchange transfusions in 90 infants with birth weight less than or equal to 1,250 gm was reviewed. Twenty percent of the infants developed cicatricial RLF. Exchange transfusion was not related to development of cicatricial RLF. The incidence of RLF in infants receiving greater or equal to 130 ml of packed red blood cells per kilogram of birth weight as replacement blood transfusion (RBT) was significantly higher (42.9%) than that in infants receiving 61 to 131 ml of packed red blood cells per kilogram (15.4%) and infants receiving less than or equal to 60 ml of packed red blood cells per kilogram (0%), P less than .001. The need for RBT, however, was strongly correlated (r = .85, P less than .001) with increasing duration of O2 therapy. When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P = .07). The association between RBT and RLF remained significant when adjusted for duration of therapy in fractional inspired oxygen (FIO2) greater than 0.4. Further detailed studies of large numbers of susceptible infants are warranted to assess the magnitude of the contribution of transfusions of adult blood to development of RLF.
研究了输注成人血液对极低出生体重儿晶状体后纤维增生症（RLF）发生发展的相对影响。回顾了90例出生体重小于或等于1250克的婴儿扩大使用置换输血和换血疗法的5年经验。20%的婴儿发生了瘢痕性RLF。换血疗法与瘢痕性RLF的发生无关。每千克出生体重接受≥130毫升浓缩红细胞作为置换输血（RBT）的婴儿中RLF的发生率（42.9%）显著高于每千克接受61至131毫升浓缩红细胞的婴儿（15.4%）和每千克接受≤60毫升浓缩红细胞的婴儿（0%），P<0.001。然而，RBT的需求与吸氧治疗时间的延长密切相关（r = 0.85，P<0.001）。当对吸氧治疗进行控制时，RBT与RLF之间的关联未达到统计学显著性（P = 0.07）。当对吸入氧分数（FIO₂）大于0.4的治疗时间进行校正时，RBT与RLF之间的关联仍然显著。有必要对大量易感婴儿进行进一步详细研究，以评估输注成人血液对RLF发生发展的影响程度。
