Clark C, Gibbs J A, Maniello R, Outerbridge E W, Aranda J V
Acta Paediatr Scand. 1981 Jul;70(4):537-9. doi: 10.1111/j.1651-2227.1981.tb05736.x.
The effect of blood transfusion on the occurrence of RLF was evaluated in 58 infants who weighed less than 1001 g at birth (Group I) and 70 oxygen treated infants of various birth weights (Group II). Although there was no significant difference between Group I infants with or without exchange transfusion as to birth weight, gestational age, duration of oxygen therapy, peak Pa02's, or multiple births, there was a significantly increased incidence of pre-retrolental fibroplasia in transfused over non-transfused Group II infants. When Group II infants were stratified for prematurity and oxygen duration, this difference persisted in those not already at risk for RLF. This increased incidence of retinopathy in transfused infants suggests that blood transfusion may be a risk factor in the pathogenesis of RLF.
对58例出生时体重不足1001克的婴儿（第一组）和70例不同出生体重的接受氧疗的婴儿（第二组），评估输血对晶状体后纤维增生症（RLF）发生情况的影响。虽然第一组中接受或未接受换血治疗的婴儿在出生体重、胎龄、氧疗持续时间、最高动脉血氧分压（Pa02）或多胎方面无显著差异，但第二组中接受输血的婴儿与未接受输血的婴儿相比，晶状体后纤维增生症的发病率显著增加。当根据早产情况和氧疗持续时间对第二组婴儿进行分层时，这种差异在那些尚无RLF风险的婴儿中依然存在。输血婴儿中视网膜病变发病率的增加表明，输血可能是RLF发病机制中的一个风险因素。
