早期红细胞输血与严重早产儿视网膜病变的发生有关。
Early red cell transfusion is associated with development of severe retinopathy of prematurity.
机构信息
Department of Pediatrics, Division of Neonatology, Saint Louis University, St. Louis, MO, USA.
Edward Mallinckrodt Department of Pediatrics, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
出版信息
J Perinatol. 2019 Mar;39(3):393-400. doi: 10.1038/s41372-018-0274-9. Epub 2018 Nov 20.
OBJECTIVE
To evaluate the association between early (within 10 d) pRBC transfusion and the development of severe ROP.
STUDY DESIGN AND METHODS
This was a single-center retrospective study. Inclusion criteria were preterm infants born ≤32 weeks gestation or weighing ≤1500 g. Severe ROP was defined as infants requiring retinal laser ablation or bevacizumab injection. Logistic regression was used to identify the association between transfusions and severe ROP.
RESULTS
A total of 1635 infants were included in the final analysis. The severe ROP incidence was 8% (126/1635). Ninety-one percent (115/126) of infants who developed severe ROP received a pRBC transfusion in the first 10 d. Early transfusion was associated with severe ROP; adjusted odds ratio of 3.8 (95% CI: 1.8-8.1).
CONCLUSION
pRBC transfusions in the first 10 days of life are associated with an almost four-fold increased risk of severe ROP, independent of gestational age at birth or bronchopulmonary dysplasia (BPD) status.
目的
评估出生后 10 天内（早期）输血与严重 ROP 发生之间的相关性。
研究设计与方法
这是一项单中心回顾性研究。纳入标准为胎龄≤32 周或出生体重≤1500g 的早产儿。严重 ROP 定义为需要视网膜激光光凝或贝伐单抗注射的婴儿。采用 logistic 回归分析输血与严重 ROP 之间的相关性。
结果
共有 1635 例婴儿纳入最终分析。严重 ROP 的发生率为 8%（126/1635）。在发生严重 ROP 的 126 例婴儿中，91%（115/126）在出生后 10 天内接受了 pRBC 输血。早期输血与严重 ROP 相关；校正后的比值比为 3.8（95%CI：1.8-8.1）。
结论
出生后 10 天内输血与严重 ROP 的发生风险增加近四倍有关，与胎龄或支气管肺发育不良（BPD）状态无关。
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