Noma T, Shimozawa K, Sakurada N, Yata J, Shishiba Y, Ozawa Y, Inatuki B
Nihon Naibunpi Gakkai Zasshi. 1982 Jan 20;58(1):1-8. doi: 10.1507/endocrine1927.58.1_1.
Anti-thyroglobulin antibody forming cells (AFC) were generated from the cultured peripheral lymphocytes of patients with chronic thyroiditis. In order to clarify whether this reflects the antibody formation in vivo, the number of antibody forming cells generated in the culture was related to the serum antibody titer in 121 cases. There was no case which produced more than 10 AFC from 2 x 10(5) B-cells in the group with the low serum antibody titer (less than 10(2)), while 29.4% produced more than 10 AFC in the patients with antibody titer of 20(2) and 20(4) and 65.2% in the group with titer of 80(2) approximately 640(2). The average number of AFC of the last group was 31.4 +/- 17.7 (SD). AFC and serum antibody titers were estimated on various occasions with the same patients. A good relationship was observed between these two parameters. There was no significant correlation between the numbers of AFC and serum antimicrosome antibody titers.
抗甲状腺球蛋白抗体形成细胞（AFC）由慢性甲状腺炎患者培养的外周淋巴细胞产生。为了阐明这是否反映体内抗体形成情况，对121例患者培养物中产生的抗体形成细胞数量与血清抗体滴度进行了关联分析。血清抗体滴度低（低于10²）的组中，没有病例从2×10⁵个B细胞产生超过10个AFC，而抗体滴度为20²和20⁴的患者中29.4%产生超过10个AFC，滴度为80²至约640²的组中65.2%产生超过10个AFC。最后一组的AFC平均数量为31.4±17.7（标准差）。在不同时间对同一患者估计AFC和血清抗体滴度。观察到这两个参数之间有良好的相关性。AFC数量与血清抗微粒体抗体滴度之间无显著相关性。
