甲状腺抗体由甲状腺来源的淋巴细胞产生。
Thyroid antibodies are produced by thyroid-derived lymphocytes.
作者信息
Weetman A P, McGregor A M, Lazarus J H, Hall R
出版信息
Clin Exp Immunol. 1982 Apr;48(1):196-200.
Abstract
The significance of the characteristic lymphocytic infiltrate in the target organ in organ-specific autoimmune disease is unknown. We have demonstrated the production of thyroglobulin antibodies and immunoglobulins (IgG, IgM and IgA) by thyroid-derived lymphocytes in Graves' disease and Hashimoto's thyroiditis two plaque forming cell (PFC) assays. The thyroid appears to be an important site of thyroglobulin antibody production but the thyroid lymphocytes also contain many IgG PFCs of non-thyroglobulin specificity. Short-term culture and direct thyroglobulin antibody assay on micro-ELISA plates confirmed the results of the PFC assay. Therapies such as carbimazole may therefore be acting on a localized source of autoantibody production.
摘要
器官特异性自身免疫疾病中靶器官特征性淋巴细胞浸润的意义尚不清楚。我们通过两种空斑形成细胞（PFC）试验，证实了格雷夫斯病和桥本甲状腺炎中甲状腺来源的淋巴细胞可产生甲状腺球蛋白抗体和免疫球蛋白（IgG、IgM和IgA）。甲状腺似乎是甲状腺球蛋白抗体产生的重要部位，但甲状腺淋巴细胞中也含有许多非甲状腺球蛋白特异性的IgG PFC。在微量ELISA板上进行短期培养和直接甲状腺球蛋白抗体检测，证实了PFC试验的结果。因此，诸如卡比马唑之类的治疗可能作用于自身抗体产生的局部来源。
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本文引用的文献
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Spontaneous plaque-forming human lymphocytes detected with the protein-A plaque assay.用蛋白A空斑试验检测到的自发形成空斑的人淋巴细胞。
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Analysis by a plaque assay of IgG- or IgM- dependent cytolytic lymphocytes in human blood.通过噬斑测定法对人血液中依赖IgG或IgM的溶细胞性淋巴细胞进行分析。
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A plaque assay for all cells secreting Ig of a given type or class.针对所有分泌特定类型或类别的免疫球蛋白的细胞进行的噬斑测定。
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