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[胸腺因子对胸腺切除大鼠血液凝固和纤维蛋白溶解的影响]

[Effect of the thymic factor on blood coagulation and fibrinolysis in thymectomized rats].

作者信息

Kuznik B I, Tsybikov N N, Molchanova N L, Morozov V G, Khavinson V Kh

出版信息

Probl Endokrinol (Mosk). 1982 Jul-Aug;28(4):77-80.

PMID:6896916
Abstract

Hypercoagulation and fibrinolysis inhibition are seen in adult rats 6 to 6 1/2 months after thymectomy. Hemocuagulation accelerating is caused by the shortened 1st phase of the blood coagulation process. Fibrinolysis delay is partially produced by a decrease in the fibrinalytic agent concentration and smooth elevation of the antiplasmin level. The most part of the coagulogram indices and fibrinolysis activation returns to normal in operated animals following the injection of a low-molecular polypeptide thymic factor within 5 days.

摘要

在成年大鼠胸腺切除术后6至6个半月可观察到高凝状态和纤维蛋白溶解抑制。凝血加速是由凝血过程第一阶段缩短所致。纤维蛋白溶解延迟部分是由于纤溶因子浓度降低和抗纤溶酶水平平稳升高引起的。在术后动物注射低分子多肽胸腺因子后5天内,大部分凝血图指标和纤维蛋白溶解激活恢复正常。

相似文献

1
[Effect of the thymic factor on blood coagulation and fibrinolysis in thymectomized rats].[胸腺因子对胸腺切除大鼠血液凝固和纤维蛋白溶解的影响]
Probl Endokrinol (Mosk). 1982 Jul-Aug;28(4):77-80.
2
[Effect of adrenaline and thymic factor on blood coagulation and fibrinolysis in healthy and thymectomized rats].[肾上腺素和胸腺因子对健康大鼠及胸腺切除大鼠血液凝固和纤维蛋白溶解的影响]
Biull Eksp Biol Med. 1981 Sep;92(9):264-6.
3
[Effect of thymalin and heterotransfusion on blood coagulation and fibrinolysis in thymectomized rats].[胸腺素与异种输血对去胸腺大鼠血液凝固及纤维蛋白溶解的影响]
Biull Eksp Biol Med. 1983 Feb;95(2):26-8.
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[Effect of histamine and thymarin on blood coagulation and fibrinolysis in intact and thymectomized rats].[组胺和胸腺素对完整及胸腺切除大鼠血液凝固和纤维蛋白溶解的影响]
Biull Eksp Biol Med. 1982 Sep;94(9):27-9.
5
[Role of the thymus in regulating blood coagulation and fibrinolysis].[胸腺在调节血液凝固和纤维蛋白溶解中的作用]
Fiziol Zh SSSR Im I M Sechenova. 1982 Jan;68(1):52-8.
6
[Regulation of the fluid state of the blood in thymectomized rats following intravenous thrombin administration].
Biull Eksp Biol Med. 1981 Sep;92(9):285-7.
7
[Effect of pregnancy on the state of the hemostatic system in intact and thymectomized rats].[妊娠对未切除胸腺和切除胸腺大鼠止血系统状态的影响]
Biull Eksp Biol Med. 1983 Oct;96(10):26-8.
8
[Effect of thymalin on the function of the blood kallikrein-kinin system in thymectomized rats].
Biull Eksp Biol Med. 1985 Jun;99(6):654-6.
9
[Effect of thymalin on blood coagulation and fibrinolysis].
Farmakol Toksikol. 1981 Jul-Aug;44(4):422-5.
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Effect of thymic humoral factor (THF) on hemopoiesis in neonatally thymectomized mice.胸腺体液因子(THF)对新生期切除胸腺小鼠造血作用的影响。
Thymus. 1987;9(4):257-9.