Kuznik B I, Pisarevskaia L I, Morozov V G, Khavinson V Kh, Tsybikov N N
Biull Eksp Biol Med. 1982 Sep;94(9):27-9.
It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation. As compared to the intact animals, administration of histamine to the thymectomized animals led to unbalance between marked acceleration of blood coagulation and a comparatively insignificant activation of fibrinolysis. This was one of the main causes of the death of the operated on animals. Low-molecular thymus factor--thymaline--not only abolishes the shifts on the part of the hemostatic system in the thymectomized animals but also recovers adequate responses of the blood coagulation and fibrinolysis systems to histamine administration, thereby contributing to the life preservation of the experimental animals.
在对胸腺切除大鼠的实验中发现，动物在手术后2 - 3个月出现高凝状态，这是由于凝血酶原酶形成时间缩短以及总优球蛋白溶解和依赖哈格曼因子的优球蛋白溶解受到抑制所致。与未做手术的动物相比，给胸腺切除的动物注射组胺会导致血液凝固明显加速与纤维蛋白溶解相对不显著激活之间的失衡。这是手术动物死亡的主要原因之一。低分子胸腺因子——胸腺素——不仅消除了胸腺切除动物止血系统的变化，还恢复了凝血和纤维蛋白溶解系统对组胺注射的适当反应，从而有助于实验动物的存活。
