Gross D M, Weitz D
J Pharmacol Methods. 1982 Sep;8(2):151-9. doi: 10.1016/0160-5402(82)90069-9.
The automation of an isolated atria assay is described. Data acquisition, operation of the strip chart recorder, data reduction and manipulation and generation of notebook pages showing final EC50's, dose-ratios and local pA2's has been completely automated. The data are acquired via a SYM-1 (6502 CPU) 8-bit single board computer running an assembly language program stored on an EPROM chip. The data from a physiological recorder system are stored by the SYM-1 and, at the conclusion of the experiment, transmitted to a DEC MINC-11 microminicomputer running a sequence of programs in BASIC for the mathematical manipulation of the data and the automatic generation of lab notebook pages. The automated system totally eliminates hand transcription of data, manual plotting of curves and mathematical errors.
本文描述了一种离体心房试验的自动化方法。数据采集、长条图记录仪的操作、数据简化与处理以及显示最终半数有效浓度（EC50）、剂量比和局部拮抗参数（pA2）的实验记录页面生成均已完全自动化。数据通过运行存储在EPROM芯片上的汇编语言程序的SYM - 1（6502 CPU）8位单板计算机采集。生理记录仪系统的数据由SYM - 1存储，实验结束时传输到运行一系列BASIC程序的DEC MINC - 11微型计算机，用于数据的数学处理和实验记录页面的自动生成。该自动化系统完全消除了数据的手工转录、曲线的手工绘制以及数学误差。
