Wick G, Schauenstein K, Thunold S, Boyd R L
Mol Immunol. 1982 Oct;19(10):1267-73. doi: 10.1016/0161-5890(82)90292-9.
This paper summarizes data obtained in our laboratory on the demonstration of receptors for IgG-Fc (FcR) and complement (CR) on mononuclear cells of the fowl. A clearcut distinction of these two structures on spleen cells was achieved in rosette assays using SRBC coated with rabbit IgG as indicator cells which bind avian complement, but are not bound by the FcR. The tissue distribution and localization of FcR and CR positive cells was studied in mixed hemadsorption assays on sections of both central (bursa, thymus) and peripheral (spleen) lymphoid organs from normal chickens, as well as lymphocytic infiltrated thyroid glands from animals of the Obese strain (OS) afflicted with spontaneous autoimmune thyroiditis. The possible significance of both receptors in the pathogenesis of this autoimmune process is discussed.
本文总结了我们实验室在禽类单核细胞上证明IgG-Fc受体（FcR）和补体受体（CR）所获得的数据。在以包被兔IgG的SRBC作为指示细胞的玫瑰花结试验中，实现了对脾细胞上这两种结构的明确区分，该指示细胞可结合禽补体，但不被FcR结合。在正常鸡的中枢（法氏囊、胸腺）和外周（脾）淋巴器官切片以及患有自发性自身免疫性甲状腺炎的肥胖品系（OS）动物的淋巴细胞浸润甲状腺切片上，通过混合血细胞吸附试验研究了FcR和CR阳性细胞的组织分布和定位。讨论了这两种受体在这种自身免疫过程发病机制中的可能意义。
