The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B.
作者信息
Nagabhushan T L, Cooper A B, Tsai H, Daniels P J, Miller G H
出版信息
J Antibiot (Tokyo). 1978 Jul;31(7):681-7. doi: 10.7164/antibiotics.31.681.
PMID:690003
Abstract
The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated sch 20287 and Sch 21420, respectively, by procedures similar to those developed by KAWAGUCHI and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological properties of Sch 20287 and Sch 21420 are compared with amikacin, gentamicin and tobramycin.
摘要
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