对妥布霉素、阿米卡星、西索米星和庆大霉素耐药的革兰氏阴性杆菌。
Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods.
作者信息
Drasar F A, Farrell W, Maskell J, Williams J D
出版信息
Br Med J. 1976 Nov 27;2(6047):1284-7. doi: 10.1136/bmj.2.6047.1284.
Abstract
Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.
摘要
对196株耐庆大霉素革兰阴性杆菌和212株对庆大霉素敏感的类似菌株（主要从临床标本中分离得到）的庆大霉素、西索米星、妥布霉素和阿米卡星敏感性进行了比较。阿米卡星是对耐庆大霉素菌株活性最强的氨基糖苷类药物，铜绿假单胞菌、克雷伯菌属、大肠埃希菌、变形杆菌属、普罗威登斯菌属和柠檬酸杆菌属尤其敏感。大多数耐庆大霉素菌株是从接受手术患者的尿液中分离得到的。庆大霉素是对庆大霉素敏感的大肠埃希菌、奇异变形杆菌和沙雷菌属活性最强的抗生素。铜绿假单胞菌和其他假单胞菌属对妥布霉素最敏感。
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