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豚鼠的I区。II. 功能分析。

The guinea pig I region. II. Functional analysis.

作者信息

Shevach E M, Lundquist M L, Geczy A F, Schwartz B D

出版信息

J Exp Med. 1977 Aug 1;146(2):561-70. doi: 10.1084/jem.146.2.561.

DOI:10.1084/jem.146.2.561
PMID:69005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180755/
Abstract

We have examined whether an association exists between specific Ia antigen genes and Ir genes which are encoded within the same haplotype. Functionally monospecific sera to the Ia antigens of the guinea pig MHC were selective in their ability to inhibit antigen-specific T-cell proliferation and we were thus able to demonstrate an association between individual Ia specificities and specific Ir genes. The results of these studies in inbred animals were confirmed by examining the association of Ir genes and Ia antigens in the outbred guinea pig population. Of great interest was the observation that antisera made against cross-reactive Ia antigens of strains lacking specific Ir genes would still inhibit immune responses of strains possessing the Ir gene, if the Ir gene was associated with that Ia antigen in the responder strain.

摘要

我们已经研究了特定的Ia抗原基因与位于同一单倍型内编码的Ir基因之间是否存在关联。针对豚鼠MHC的Ia抗原具有功能单特异性的血清在抑制抗原特异性T细胞增殖的能力上具有选择性，因此我们能够证明个体Ia特异性与特定Ir基因之间存在关联。通过检测远交豚鼠群体中Ir基因与Ia抗原的关联，这些近交动物研究的结果得到了证实。一个非常有趣的观察结果是，如果Ir基因在反应品系中与该Ia抗原相关联，那么针对缺乏特定Ir基因品系的交叉反应性Ia抗原制备的抗血清仍会抑制具有该Ir基因品系的免疫反应。

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