用针对I-A或I-C亚区产物的抗Ia抗血清抑制双Ir基因控制的T淋巴细胞对聚（Glu56Lys35Phe9）n的增殖反应。
Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion.
作者信息
Schwartz R H, David C S, Dorf M E, Benacerraf B, Paul W E
出版信息
Proc Natl Acad Sci U S A. 1978 May;75(5):2387-91. doi: 10.1073/pnas.75.5.2387.
Abstract
Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu53Lys36Phe11)n (GLphi) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GL phi-alpha, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-GL phi-beta, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lyphocyte proliferative response to GL phi. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLphi. These results suggest that a function mediated by two Ir gene products can be blocked by anit-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.
摘要
先前的研究表明，针对聚（Glu53Lys36Phe11）n（GLphi）的抗体和T淋巴细胞增殖免疫反应均受两个主要组织相容性连锁免疫反应（Ir）基因的控制。一个基因，称为Ir-GL phi-α，已被定位到主要组织相容性复合体的I-C或I-E亚区，而另一个，称为Ir-GL phi-β，已被定位到I-A亚区。在本文中，我们研究了抗I区相关（Ia）抗血清对T淋巴细胞对GL phi增殖反应的影响。发现针对I-A或I-C亚区基因编码的Ia抗原的抗体可抑制对GLphi的增殖反应。这些结果表明，由两种Ir基因产物介导的功能可以被针对其中任何一种的抗Ia抗血清阻断，因此，这两种产物都在细胞表面表达。
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Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion.用针对I-A或I-C亚区产物的抗Ia抗血清抑制双Ir基因控制的T淋巴细胞对聚（Glu56Lys35Phe9）n的增殖反应。
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