对用一系列硝基苯基化合物修饰的H-2匹配靶细胞的细胞介导淋巴细胞溶解作用。
Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.
作者信息
Rehn T G, Inman J K, Shearer G M
出版信息
J Exp Med. 1976 Oct 1;144(4):1134-40. doi: 10.1084/jem.144.4.1134.
Abstract
The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.
摘要
研究了用一系列相关硝基苯基化合物修饰的自体脾细胞进行体外致敏所产生的C57BL / 10细胞毒性效应细胞的特异性。三硝基苯基（TNP）致敏的效应细胞不能裂解TNP-β-丙氨酰甘氨酰甘氨酰（AGG）修饰的靶细胞，这一结果被作为与最简单形式的T细胞识别的紧密性或双受体模型相矛盾的证据。还显示的数据表明，用N-（3-硝基-4-羟基-5-碘苯基乙酰基）-AGG修饰的刺激细胞致敏可产生细胞毒性效应细胞的非交叉反应克隆。
相似文献
1
Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.对用一系列硝基苯基化合物修饰的H-2匹配靶细胞的细胞介导淋巴细胞溶解作用。
J Exp Med. 1976 Oct 1;144(4):1134-40. doi: 10.1084/jem.144.4.1134.
2
Cell-mediated lympholysis of N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-beta-anaylglycylglycyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2K and H-2D serological regions of the murine major histocompatibility complex.N-（3-硝基-4-羟基-5-碘苯乙酰基）-β-丙氨酰甘氨酰修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。效应细胞对由小鼠主要组织相容性复合体的H-2K和H-2D血清学区域控制的修饰细胞表面成分的特异性。
J Exp Med. 1976 Jan 1;143(1):127-42. doi: 10.1084/jem.143.1.127.
3
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。效应细胞对由小鼠主要组织相容性复合体的H-2K和H-2D血清学区域控制的修饰细胞表面成分的特异性。
J Exp Med. 1975 Jun 1;141(6):1348-64. doi: 10.1084/jem.141.6.1348.
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Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.H-2 D相关的T细胞介导的对三硝基苯基修饰的自体细胞的淋巴细胞溶解的多个H-2连锁免疫反应基因控制：定位于I-A左侧和I区内的类Ir基因。
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On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets.关于H-2组织相容性复合体在确定针对同基因三硝基苯基修饰靶标的细胞毒性效应细胞特异性中的作用。
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Bifunctional major histocompatibility-linked genetic regulation of cell-mediated lympholysis to trinitrophenyl-modified autologous lymphocytes.对三硝基苯修饰的自体淋巴细胞的细胞介导淋巴细胞溶解的双功能主要组织相容性连锁基因调控。
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Fine specificity of cytotoxic T lymphocytes: C57BL effector cells induced by autologous cells modified with hapten (4-hydroxy-3-nitro-phenyl)acetyl (NIP) are not heteroclitic.细胞毒性T淋巴细胞的精细特异性：用半抗原（4-羟基-3-硝基苯基）乙酰基（NIP）修饰的自体细胞诱导产生的C57BL效应细胞不存在交叉反应。
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Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):211-7. doi: 10.1084/jem.143.1.211.
引用本文的文献
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Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin.针对流感病毒血凝素的细胞毒性T细胞的特异性
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J Exp Med. 1978 Apr 1;147(4):1065-77. doi: 10.1084/jem.147.4.1065.
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Viral specificity of H-2-restricted T killer cells directed against syngeneic tumors induced by Gross, Friend, or Rauscher leukemia virus.针对由格罗斯、弗里德或劳舍尔白血病病毒诱导的同基因肿瘤的H-2限制性T杀伤细胞的病毒特异性。
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Coupling of large haptens to proteins and cell surfaces: preparation of stable, optimally sensitized erythrocytes for hapten-specific, hemolytic plaque assays.大分子半抗原与蛋白质及细胞表面的偶联：制备用于半抗原特异性溶血空斑试验的稳定、最佳致敏红细胞。
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Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.淋巴细胞性脉络丛脑膜炎中致敏T淋巴细胞对自身成分改变的免疫监视。
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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
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Antigen recognition and the immune response. Humoral and cellular immune responses to small mono- and bifunctional antigen molecules.抗原识别与免疫反应。对小型单功能和双功能抗原分子的体液免疫和细胞免疫反应。
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Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
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T-lymphocytes response to Friend virus-induced tumour cell lines in mice of strains congenic at H--2.H-2基因座同基因小鼠中T淋巴细胞对Friend病毒诱导的肿瘤细胞系的反应。
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The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).在对聚（谷氨酸53-赖氨酸36-苯丙氨酸11）的T淋巴细胞增殖反应中，对两个互补的Ir-GLphi免疫反应基因的需求。
J Exp Med. 1976 Apr 1;143(4):897-905. doi: 10.1084/jem.143.4.897.
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