通过对强同种抗原进行阴性选择的淋巴细胞群体产生针对三硝基苯基修饰的同种异体靶标的杀伤细胞。
The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.
作者信息
Wilson D B, Lindahl K F, Wilson D H, Sprent J
出版信息
J Exp Med. 1977 Aug 1;146(2):361-7. doi: 10.1084/jem.146.2.361.
Abstract
Negatively selected mouse and rat lymphocyte populations, specifically deprived of alloreactivity to a particular major histocompatibility complex (MHC) haplotype, are nevertheless fully capable of responding to trinitrophenyl (TNP)-modified allogeneic stimulator cells and developing cytotoxic T-lymphocyte activity to TNP-altered allogeneic target cells. As for syngeneic systems, lytic expression of those responder killer cells also requires MHC identity between the target and stimulator cell populations. Such a finding argues strongly against two variations of the dual recognition hypothesis: like-like interactions and adaptive differentiation. Instead, these data favor either the altered self model or a third variation of the dual receptor model, where one of the relevent receptors is specific for the modifying antigen and the second is a low affinity receptor unable to be triggered in the absence of a modifying antigen.
摘要
经过阴性选择的小鼠和大鼠淋巴细胞群体，虽然对特定的主要组织相容性复合体（MHC）单倍型完全没有同种异体反应性，但仍完全能够对三硝基苯基（TNP）修饰的同种异体刺激细胞作出反应，并对TNP改变的同种异体靶细胞产生细胞毒性T淋巴细胞活性。至于同基因系统，那些反应性杀伤细胞的裂解表达也需要靶细胞群体和刺激细胞群体之间的MHC一致性。这一发现有力地反驳了双重识别假说的两种变体：同类相互作用和适应性分化。相反，这些数据支持改变自身模型或双重受体模型的第三种变体，即其中一个相关受体对修饰抗原具有特异性，另一个是低亲和力受体，在没有修饰抗原的情况下无法被触发。
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The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.通过对强同种抗原进行阴性选择的淋巴细胞群体产生针对三硝基苯基修饰的同种异体靶标的杀伤细胞。
J Exp Med. 1977 Aug 1;146(2):361-7. doi: 10.1084/jem.146.2.361.
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本文引用的文献
1
Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
Eur J Immunol. 1974 Aug;4(8):527-33. doi: 10.1002/eji.1830040802.
2
Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats.F1杂种大鼠循环淋巴细胞在接触组织相容性抗原后出现的特异性无反应性。
Nat New Biol. 1971 Dec 8;234(49):178-80. doi: 10.1038/newbio234178a0.
3
The clonal nature of allo-antigen-sensitive small lymphocytes in the recirculating pool of normal rats.正常大鼠循环池中同种异体抗原敏感小淋巴细胞的克隆性质。
Aust J Exp Biol Med Sci. 1974 Feb;52(1):45-66. doi: 10.1038/icb.1974.4.
4
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.针对同基因三硝基苯（TNP）脾细胞产生的细胞毒性T淋巴细胞对三硝基苯衍生化的H-2不相容靶细胞的交叉反应性裂解。
J Exp Med. 1976 Dec 1;144(6):1609-20. doi: 10.1084/jem.144.6.1609.
5
Role of major histocompatibility complex gene products in delayed-type hypersensitivity.主要组织相容性复合体基因产物在迟发型超敏反应中的作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2486-90. doi: 10.1073/pnas.73.7.2486.
6
Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells.细胞毒性T淋巴细胞识别同种异体耐受的三硝基苯结合细胞。
Nature. 1976 May 13;261(5556):141-2. doi: 10.1038/261141a0.
7
T-lymphocytes response to Friend virus-induced tumour cell lines in mice of strains congenic at H--2.H-2基因座同基因小鼠中T淋巴细胞对Friend病毒诱导的肿瘤细胞系的反应。
Nature. 1976 Mar 18;260(5548):250-2. doi: 10.1038/260250a0.
8
Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.针对H-2不相容靶细胞的病毒和三硝基苯酚半抗原特异性T细胞介导的细胞毒性。
J Exp Med. 1976 Apr 1;143(4):999-1004. doi: 10.1084/jem.143.4.999.
9
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.
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In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
J Exp Med. 1975 Nov 1;142(5):1108-20. doi: 10.1084/jem.142.5.1108.
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