布-2313，一种对厌氧菌有活性的新型抗生素复合物。I. 布-2313 A和B的产生、分离及特性

Bu-2313, a new antibiotic complex active against anaerobes. I. Production, isolation and properties of Bu-2313 A and B.

作者信息

Tsukiura H, Tomita K, Hanada M, Kobaru S, Tsunakawa M, Fujisawa K, Kawaguchi H

出版信息

J Antibiot (Tokyo). 1980 Feb;33(2):157-65. doi: 10.7164/antibiotics.33.157.

DOI:10.7164/antibiotics.33.157

Abstract

An unidentified oligosporic actinomycete strain, No. E864-61, produced two new antibiotics, Bu-2313 A (C27H35NO9) and Bu-2313 B (C26H33NO9). Bu-2313 A and B each exhibited a broad antibiotic spectrum against Gram-positive and Gram-negative anaerobic bacteria, and showed in vivo activity against experimental infections produced by B. fragilis and C. perfringens. Bu-2313 also inhibited some aerobic bacteria such as streptococci. Bu-2313 B was approximately two-fold more active than Bu-2313 A.

摘要

一株未鉴定的寡孢放线菌菌株E864 - 61产生了两种新抗生素，Bu - 2313 A（C27H35NO9）和Bu - 2313 B（C26H33NO9）。Bu - 2313 A和B对革兰氏阳性和革兰氏阴性厌氧菌均表现出广谱抗菌活性，并对脆弱拟杆菌和产气荚膜梭菌引起的实验性感染具有体内活性。Bu - 2313还能抑制一些需氧菌，如链球菌。Bu - 2313 B的活性约为Bu - 2313 A的两倍。