Warren S E, O'Connor D T
Am J Med. 1980 Sep;69(3):425-9. doi: 10.1016/0002-9343(80)90015-7.
Clinical and epidemiologic data support the contention that black people have a higher incidence and severity of essential hypertension than white people, a phenomenon which is likely due to genetic factors. Physiologic profiles in such patients reveal a striking prevalence of low renin, volume-expanded hypertension, with an exaggerated propensity to sodium retention. A deficiency in the natriuretic, vasodilatory renal kallikrein-kinin system may explain these phenomena and may be of practical importance in the selection of therapy.
临床和流行病学数据支持这样一种观点，即黑人原发性高血压的发病率和严重程度高于白人，这种现象可能是由遗传因素导致的。这类患者的生理特征显示，低肾素、容量扩张型高血压极为普遍，且钠潴留倾向明显增强。利钠、血管舒张性肾激肽 - 激肽系统的缺陷可能解释了这些现象，并且在治疗方案的选择上可能具有实际重要性。
