Desjars P, Pinaud M, Baron D, Rodineau P, Nicolas R
Intensive Care Med. 1978 Jul;4(3):123-5. doi: 10.1007/BF01700252.
Nine patients hospitalized for tetanus were studied under the same protocol which included two haemodynamic studies with a preload trial (PLT). The first being made during therapy (diazepam barbiturate association), on the sixth day of hospitalisation, and the second one after recovery. The comparison of the results shows that before PLT the mean arterial pressuure (MAP) is significantly increased (p less than 0.05) in patients after recovery in comparison to the same patients undergoing therapy. After PLT there is no significant difference between the two groups. Lastly, the variation of the left ventricular function points under PLT shows no significant difference between patients during therapy and after recovery. These results suggest that the diazepamphenobarbital combination does not alter the left ventricular function of the patients undergoing this therapy during tetanus.
对9名因破伤风住院的患者按照相同方案进行了研究，该方案包括两项带有预负荷试验（PLT）的血流动力学研究。第一次研究在治疗期间（地西泮与巴比妥类药物联合使用）、住院第6天时进行，第二次在康复后进行。结果比较显示，与接受治疗的同一批患者相比，康复后的患者在PLT前平均动脉压（MAP）显著升高（p<0.05）。PLT后两组之间无显著差异。最后，PLT下左心室功能点的变化显示治疗期间和康复后的患者之间无显著差异。这些结果表明，地西泮-苯巴比妥联合用药不会改变破伤风患者在接受该治疗期间的左心室功能。
