Hoyng P F, Dake C L
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(4):269-75. doi: 10.1007/BF00417523.
Over a period of 4 months, 16 of 24 patients (30 of 46 eyes) with either primary open angle glaucoma (POAG) or suspected glaucoma were treated successfully with a maintenance dose of guanethidine (3%) and adrenaline (0.5%) combined in one eyedrop (GA) once daily. In the previous month the medication was given twice daily and at the end of 4 months the decrease in intraocular pressure (IOP) was 8.9 mm Hg (33%) compared to 9.9 mm Hg (37%) with twice-daily application; three of four eyes responded just as well to single-daily application as to twice daily application of GA. Once-daily treatment with GA was not successful when the average IOP in the absence of treatment was over 32 mm Hg. The advantages of once-daily application were less conjunctival hyperemia, less dilation of the pupils, less ptosis and difficulty reading, plus the advantage that the drops needed only to be applied once a day (patient compliance). The recommended regime for GA therapy in patients with an IOP of less than 32 mm Hg is application of GA twice daily for 1 month followed by a decrease in the dosage to once a day. GA can best be applied in the evening before retiring.
在4个月的时间里，24例原发性开角型青光眼（POAG）或疑似青光眼患者中的16例（46只眼中的30只），使用含胍乙啶（3%）和肾上腺素（0.5%）的复方滴眼液（GA）维持剂量成功治疗，每日滴眼1次。前1个月每日滴眼2次，4个月末眼压（IOP）下降了8.9 mmHg（33%），而每日滴眼2次时眼压下降了9.9 mmHg（37%）；4只眼中有3只对GA每日滴眼1次和每日滴眼2次的效果相同。当未治疗时平均眼压超过32 mmHg时，GA每日滴眼1次治疗无效。每日滴眼1次的优点是结膜充血较少、瞳孔散大较少、上睑下垂和阅读困难较少，此外还有每日只需滴眼1次的优点（患者依从性好）。对于眼压低于32 mmHg的患者，GA治疗的推荐方案是每日滴眼2次，持续1个月，然后剂量减至每日1次。GA最好在睡前晚上使用。
