Feigin I
J Neuropathol Exp Neurol. 1978 Sep;37(5):459-70. doi: 10.1097/00005072-197809000-00001.
Two spinal tumors are reported which consisted of an admixture of meningiomatous and nerve sheath tumor tissues. The former was represented by whorled tissues in both cases, syncytial areas in one and psammoma bodies in the other. The latter was represented by cells with parallel oriented, elongated nuclei and intercellular connective tissue fibers, which contained neurons and myelinated axons. Each of the tumors contained anaplastic areas of increased cellularity and atypism, in addition to the well differentiated areas. On tumor was at cervical levels in a 55 year old man; he has survived for 7 years post-operatively, but with continued pain and motor difficulties. The other was at lumber levels in a 68 year old man; died 6 weeks after operation. No autopsy was obtained. There were no stigmata of von Recklinghausen's disease in either patient. It is suggested that these tumors should not be viewed as teratoid, i.e. of mixed mesenchymal and neurectodermal character. If Schwann cells are considered mesenchymal, as is suggested in other studies, the tumors would represent mixed mesenchymal tumors, like those frequently observed elsewhere, e.g. the angiomyolipomas.
报告了两例脊髓肿瘤，其由脑膜瘤组织和神经鞘瘤组织混合而成。在两例中，前者均表现为漩涡状组织，其中一例有合体细胞区，另一例有砂粒体。后者表现为细胞核呈平行排列、细长且有细胞间结缔组织纤维的细胞，其中含有神经元和有髓轴突。除了分化良好的区域外，每个肿瘤都有细胞增多和异型性增加的间变区域。一例肿瘤发生在一名55岁男性的颈椎水平；他术后存活了7年，但持续存在疼痛和运动困难。另一例发生在一名68岁男性的腰椎水平；术后6周死亡。未进行尸检。两名患者均无冯·雷克林豪森病的体征。建议不应将这些肿瘤视为畸胎样肿瘤，即具有混合间充质和神经外胚层特征的肿瘤。如果像其他研究中所建议的那样，将施万细胞视为间充质细胞，那么这些肿瘤将代表混合性间充质肿瘤，就像在其他地方经常观察到的那样，例如血管平滑肌脂肪瘤。
