Andrews G A, Hubner K F, Greenlaw R H
J Nucl Med. 1978 Sep;19(9):1013-9.
In a large cooperative study of Ga-67 uptake in non-Hodgkin's malignant lymphoma, 76% of untreated patients showed positive uptake in one or more lesions. The percentage of known individual lesions seen on scan was significantly lower; thus, negative findings at any one site may have much less significance than positive findings. After treatment, the number of lesions seen decreases sharply, but the role of Ga-67 in evaluating response to therapy is uncertain, especially in view of the fairly large number of lesions undetectable before therapy. Histologic type plays a role in Ga-67 uptake. Large lesions are much more effectively detected than small ones. In spite of numerous false-negative results, Ga-67 scanning is a useful method in evaluating the extent of untreated disease and the presence of lesions posttherapy.
在一项关于非霍奇金恶性淋巴瘤中镓-67摄取情况的大型合作研究中，76%的未经治疗的患者在一个或多个病灶中显示出阳性摄取。扫描中发现的已知单个病灶的百分比显著更低；因此，任何一个部位的阴性结果可能比阳性结果的意义小得多。治疗后，可见病灶的数量急剧减少，但镓-67在评估治疗反应中的作用尚不确定，尤其是考虑到治疗前有相当数量的病灶无法检测到。组织学类型在镓-67摄取中起作用。大病灶比小病灶更容易被有效检测到。尽管有许多假阴性结果，但镓-67扫描在评估未经治疗疾病的范围和治疗后病灶的存在情况方面是一种有用的方法。
