Johnston G S, Go M F, Benua R S, Larson S M, Andrews G A, Hubner K F
J Nucl Med. 1977 Jul;18(7):692-8.
A large cooperative study of Ga-67 uptake in Hodgkin's disease showed that 88% of untreated patients had a positive uptake in one or more lesions. The percent of individual lesions seen on scan, however, was significantly lower; this indicated that negative findings at any one site do not argue strongly against the possiblilty of a lesion there. After treatment, the number of visualized lesions decreased sharply, but the exact role of Ga-67 in evaluating therapy is still not clear. Of the various histologic types of Hodgkin's disease, there was a high incidence of localization in all except the lymphocyte-predominance type, which showed a slightly lower uptake. No lesions less than 1 cm in diameter were successfully imaged and the size most easily detected was 4 cm in diameter. As expected, the imaging technique was much less successful for abdominal lesions than for those at other sites because of interfering concentration in bowel and liver. Both radiotherpy and chemotherapy tend to reverse the abnormalities seen on scan. The finding of a significant number of unsuspected positive lesions in asymptomatic patients returning for routine followup suggests that this is a distinctly valuable use of Ga-67, allowing early therpy for recurrences.
一项关于霍奇金病中镓 - 67摄取情况的大型合作研究表明，88%未经治疗的患者在一个或多个病灶中有阳性摄取。然而，扫描所见单个病灶的百分比显著更低；这表明在任一部位出现的阴性结果并不能有力地排除该部位存在病灶的可能性。治疗后，可见病灶的数量急剧减少，但镓 - 67在评估治疗中的确切作用仍不明确。在霍奇金病的各种组织学类型中，除淋巴细胞为主型外，其他类型在病灶定位方面的发生率都很高，淋巴细胞为主型的摄取略低。直径小于1厘米的病灶未能成功成像，最易检测到的病灶大小为直径4厘米。正如预期的那样，由于肠道和肝脏中放射性物质的干扰，腹部病灶的成像技术比其他部位病灶的成像技术成功率要低得多。放疗和化疗都倾向于使扫描所见的异常情况恢复正常。在无症状患者进行常规随访时发现大量未被怀疑的阳性病灶，这表明镓 - 67的这种应用具有显著价值，能够对复发情况进行早期治疗。
