Richardson V J, Jeyasingh K, Jewkes R F, Ryman B E, Tattersall M H
J Nucl Med. 1978 Sep;19(9):1049-54.
The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.
