Plieth M, Ache-Ebelt H, Fitzner R, Bein G, Karkut G
Z Geburtshilfe Perinatol. 1980 Aug;184(4):275-82.
We can sum up as follows: In special cases, tocolytics can lead to complications in the mother as well as in the foetus. These may be partly so severe that lead to patient's death, as some case histories show. In the majority of cases, however, there are only slight transient changes which are no longer manifest after a few weeks' time. Hence, it should be mandatory to initiate special cardiologic supervision of the children during the perinatal period if administration of tocolytics was unavoidable for the purpose of maintaining the state of pregnancy. It would be optimal if these patients, besides being examined clinically, would also be examined via echocardiogram, electrocardiogram and CK-MB determination. Since the echocardiographic examination, in particular, entails a great deal of expenditure of time and requires a relatively complicated instrumental set-up, we believe that recording the ecg and CK-MB should suffice, as practicable examination parameters in clinical routine, to detect this damage of the myocardium well in time.
在特殊情况下,宫缩抑制剂可能会导致母亲和胎儿出现并发症。正如一些病例记录所示,这些并发症有时可能非常严重,甚至导致患者死亡。然而,在大多数情况下,只有轻微的短暂变化,几周后就不再明显。因此,如果为维持妊娠状态而不可避免地使用了宫缩抑制剂,那么在围产期对儿童进行特殊的心脏监护就应成为强制性措施。如果这些患者除了进行临床检查外,还能通过超声心动图、心电图和肌酸激酶同工酶(CK-MB)测定进行检查,那将是最为理想的。由于超声心动图检查尤其需要大量时间且需要相对复杂的仪器设备,我们认为,作为临床常规可行的检查参数,记录心电图和CK-MB应足以及时很好地检测出心肌损伤。