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PC-904在儿科领域的临床研究(作者译)

[A clinical study of PC-904 in pediatric field (author's transl)].

作者信息

Aoyama R, Nagata K, Izumi Y, Kudo M, Sato S

出版信息

Jpn J Antibiot. 1978 Jul;31(7):363-5.

PMID:691259
Abstract

A clinical study of PC-904 was performed and the following results were obtained. 1) PC-904 was intravenously administered at the daily dosage of 20 approximately 120 mg/kg to 13 children; urinary tract infection (10 cases), acute pneumonia (1 case), sepsis (1 case) and purulent meningitis (1 case). The overall efficacy rate was 46.2%. 2) As to adverse reaction, eosinophilia was noted only in 2 patients. One neonate was treated with this drug, but no side effects were observed. 3) It was considered that PC-904 was a useful antibiotic drug for the second choice rather than the first.

摘要

对PC - 904进行了一项临床研究,并获得了以下结果。1)以每日约20至120mg/kg的剂量对13名儿童静脉注射PC - 904;这些儿童患有尿路感染(10例)、急性肺炎(1例)、败血症(1例)和化脓性脑膜炎(1例)。总有效率为46.2%。2)关于不良反应,仅2例患者出现嗜酸性粒细胞增多。一名新生儿接受了该药物治疗,但未观察到副作用。3)认为PC - 904是一种有用的二线抗生素药物,而非一线药物。

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