Green J H, Macdonald I A
Q J Exp Physiol. 1981 Oct;66(4):465-73. doi: 10.1113/expphysiol.1981.sp002588.
The influence of an intravenous infusion of glucose (500 ml of 20% w/v), on heat production and variables which contribute to heat loss was studied in six normal human volunteers. Mannitol (500 ml of 20% w/v) was infused on a different occasion as an osmotic control. Both infusions produced changes in haematocrit and osmolality of a similar magnitude. Heat production increased by 20% after intravenous glucose but only a small increase in heat production was observed after intravenous mannitol. Calf blood flow increased after both infusions but hand blood flow increased only after the glucose infusions. The increase in skin temperature which was observed after both infusions was associated with increases in peripheral blood flow. Core temperature decreased slightly following administration of both substances. The changes in metabolic heat production and cardiovascular function are discussed. These changes do not appear to be due to the catecholamine response to hyperglycaemia and hyperosmolality.
在六名正常人类志愿者中，研究了静脉输注葡萄糖（500毫升20%w/v）对产热以及导致热量散失的各项变量的影响。在另一个不同的时间，输注甘露醇（500毫升20%w/v）作为渗透对照。两种输注均使血细胞比容和渗透压产生了相似程度的变化。静脉输注葡萄糖后产热增加了20%，但静脉输注甘露醇后仅观察到产热有小幅增加。两种输注后小腿血流量均增加，但仅在输注葡萄糖后手部血流量增加。两种输注后观察到的皮肤温度升高与外周血流量增加有关。给予两种物质后，核心体温均略有下降。文中讨论了代谢产热和心血管功能的变化。这些变化似乎并非由于对高血糖和高渗状态的儿茶酚胺反应所致。
