对来自英国医院的金黄色葡萄球菌菌株中庆大霉素耐药性的回顾性分子分析。

A retrospective molecular analysis of gentamicin resistance in Staphylococcus aureus strains from UK hospitals.

作者信息

Wright C L, Byrne M E, Firth N, Skurray R A

机构信息

Department of Microbiology, Monash University, Clayton, Victoria, Australia.

出版信息

J Med Microbiol. 1998 Feb;47(2):173-8. doi: 10.1099/00222615-47-2-173.

DOI:10.1099/00222615-47-2-173

PMID:9879961

Abstract

The composite transposon Tn4001 and a related chromosomal Tn4001-like element, encode resistance to the aminoglycosides gentamicin, tobramycin and kanamycin (GmTmKmr) in Australian strains of Staphylococcus aureus. Southern hybridisation analysis of GmTmKmr S. aureus strains isolated from various hospitals in the UK between 1975 and 1985 indicated that they predominantly encoded chromosomal copies of Tn4001 or a Tn4001-like element. However, a strain isolated in 1985 was found to carry Tn4001 on a plasmid related to pSK1, the prototypical multiresistance plasmid commonly detected in S. aureus strains from Australian hospitals.

摘要

复合转座子Tn4001以及一个相关的染色体上类Tn4001元件，在澳大利亚的金黄色葡萄球菌菌株中编码对氨基糖苷类庆大霉素、妥布霉素和卡那霉素（GmTmKmr）的抗性。对1975年至1985年间从英国各医院分离出的GmTmKmr金黄色葡萄球菌菌株进行的Southern杂交分析表明，它们主要编码Tn4001或类Tn4001元件的染色体拷贝。然而，发现1985年分离出的一株菌株在与pSK1相关的质粒上携带Tn4001，pSK1是在澳大利亚医院的金黄色葡萄球菌菌株中常见的典型多抗性质粒。