北美黑人中的B因子多态性：新型变体Bf F1.35的研究
Factor B polymorphism in North American blacks: study of a new variant Bf F1.35.
作者信息
Nerl C, O'Neill G J
出版信息
Hum Genet. 1982;61(4):357-9. doi: 10.1007/BF00276600.
PMID:6924916
Abstract
A "new" variant of the factor B (Bf) system has been found in the serum of three individuals of a North American Black family. This variant migrates faster than Bf F1 and has been designated Bf F1.35 on account of the relative electrophoretic mobility using reference Bf typed sera. This new factor B variant (F1.35) was found to be functionally active using a specific hemolytic overlay technique and was inherited on an HLA-A28;Bw35;C4 A3,B1;C2C;DR3;GLO2 haplotype.
摘要
在一个北美黑人家庭的三名成员血清中发现了补体B因子（Bf）系统的一种“新”变体。该变体在电泳时迁移速度比Bf F1快，根据与参考Bf分型血清相比的相对电泳迁移率，被命名为Bf F1.35。利用一种特定的溶血覆盖技术发现这种新的B因子变体（F1.35）具有功能活性，并且它是通过HLA-A28;Bw35;C4 A3,B1;C2C;DR3;GLO2单倍型遗传的。
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