Bodansky H J, Cudworth A G, Drury P L, Kohner E M
Diabetes Care. 1982 Mar-Apr;5(2):97-100. doi: 10.2337/diacare.5.2.97.
The natural history of disease and suspected risk factors for bad prognosis were investigated in 40 subjects with insulin-dependent diabetes mellitus who had severe retinopathy and in 22 patients with a similar duration of diabetes without evidence of complications. The retinopathy group showed a marked excess of men (ratio 2:1). Examination of the data in the literature also showed a striking excess of men, 61% (P less than 0.001) in patients with insulin-dependent diabetes and severe microvascular disease. In addition, proliferative retinopathy was found to have significant associations with current poor diabetic control, hypertension, and previous treatment with once-daily insulin regimens, particularly with protamine zinc insulin.
对40例患有严重视网膜病变的胰岛素依赖型糖尿病患者以及22例糖尿病病程相似但无并发症迹象的患者，研究了疾病的自然史和预后不良的可疑危险因素。视网膜病变组男性明显过多（比例为2:1）。对文献数据的研究也显示男性明显过多，在患有胰岛素依赖型糖尿病和严重微血管疾病的患者中占61%（P<0.001）。此外，发现增殖性视网膜病变与当前糖尿病控制不佳、高血压以及先前使用每日一次胰岛素治疗方案，特别是鱼精蛋白锌胰岛素治疗显著相关。
