Brown L R, Handler S F, Horton I M, Streckfuss J L, Dreizen S
J Dent Res. 1980 Feb;59(2):159-67. doi: 10.1177/00220345800590021601.
A fluoride-sensitive (FS) strain of Streptococcus mutans and a laboratory-induced fluoride-resistant (FR) offspring were compared for the effects of sodium fluoride on viability and growth. There was a significant fluoride-related loss of viability in resting cell suspensions of the FS strain during a 47-hour exposure to fluoride levels above 75 ppm that was not encountered with the FR strain. The addition of 300 ppmF to actively growing six-hour broth cultures almost totally arrested the growth of the FS strain, while only slightly reducing that of the FR culture. The addition of 600 ppmF immediately terminated FS growth, and greatly reduced the rate and maximum growth of FR cultures.
比较了变形链球菌的氟敏感（FS）菌株和实验室诱导的耐氟（FR）子代，研究氟化钠对其活力和生长的影响。在暴露于75 ppm以上氟水平47小时的过程中，FS菌株的静止细胞悬液中出现了与氟相关的显著活力损失，而FR菌株未出现这种情况。向活跃生长6小时的肉汤培养物中添加300 ppmF几乎完全抑制了FS菌株的生长，而对FR培养物的生长仅略有影响。添加600 ppmF立即终止了FS菌株的生长，并大大降低了FR培养物的生长速率和最大生长量。
