Yost K G, VanDemark P J
Appl Environ Microbiol. 1978 May;35(5):920-4. doi: 10.1128/aem.35.5.920-924.1978.
Sodium fluoride caused inhibition of growth rate and growth levels of Streptococcus mutans with glucose as the primary energy and carbon source. Stannous fluoride increased growth lag nad caused a much greater inhibition of growth rate than did sodium fluoride. Neither compound was found to be bactericidal when culture viability was measured after 6 days of incubation. Leuconostoc mesenteroides, which lacks a phosphotransferase system for sugar transport, showed less inhibition of growth rate with both inhibitors than did S. mutans, which possesses a phosphotransferase system. Metabolism of glucose or lactose which requires enolase activity shoed sodium fluoride inhibition, whereas metabolism of arginine or pyruvate does not involve enolase activity and showed no inhibition of growth.
以葡萄糖作为主要能量和碳源时,氟化钠会抑制变形链球菌的生长速率和生长水平。与氟化钠相比,氟化亚锡延长了生长迟滞期,且对生长速率的抑制作用更强。在培养6天后测定培养物活力时,未发现这两种化合物具有杀菌作用。缺乏糖转运磷酸转移酶系统的肠系膜明串珠菌,与具有磷酸转移酶系统的变形链球菌相比,对这两种抑制剂的生长速率抑制作用较小。需要烯醇化酶活性的葡萄糖或乳糖代谢显示出氟化钠抑制作用,而精氨酸或丙酮酸的代谢不涉及烯醇化酶活性,且未显示出生长抑制作用。