Mayhew R R, Brown L R
J Dent Res. 1981 Oct;60(10):1809-14. doi: 10.1177/00220345810600101301.
The inhibitory effects of NaF, SnF2, and SnCl2 were compared in vitro on the growth of Streptococcus mutans NCTC No. 10449. Sodium fluoride arrested growth at 300 and 600 ppm F (while SnF2 suppressed the rate of growth at 75 ppm F), showed some bactericidal activity at 150 and 300 ppm F, and was totally bactericidal at 600 ppm F. The greater inhibition by SnF2 suggests an additive effect of SN2+. As a measure of a fluoride-free Sn2+ solution, SnCl2 was inappropriate since most of the tin present, at a neutral pH, was Sn4+. The influence of pH was particularly noteworthy with SnF2 at 600 ppm F, where a total bactericidal effect was observed within four h at pH 5.9, while viable cells were still recoverable from four to 40 h with SnF2 at pH 7.2.
在体外比较了氟化钠（NaF）、氟化亚锡（SnF₂）和氯化亚锡（SnCl₂）对变形链球菌NCTC No. 10449生长的抑制作用。氟化钠在氟含量为300 ppm和600 ppm时抑制生长（而氟化亚锡在氟含量为75 ppm时抑制生长速率），在氟含量为150 ppm和300 ppm时表现出一定的杀菌活性，在氟含量为600 ppm时具有完全杀菌作用。氟化亚锡的更强抑制作用表明Sn²⁺具有相加效应。作为一种不含氟的Sn²⁺溶液，氯化亚锡并不合适，因为在中性pH条件下，大部分锡以Sn⁴⁺形式存在。pH的影响在氟含量为600 ppm的氟化亚锡中尤为显著，在pH 5.9时，4小时内观察到完全杀菌效果，而在pH 7.2时，使用氟化亚锡在4至40小时内仍可回收活细胞。
