“微颗粒型”急性早幼粒细胞白血病：一种独特的临床、超微结构及细胞遗传学实体。
"Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity.
作者信息
Golomb H M, Rowley J D, Vardiman J W, Testa J R, Butler A
出版信息
Blood. 1980 Feb;55(2):253-9.
Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality [t (15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. However, the average granule sizes were 120, 170, and 180 nm, respectively, for the three patients, significantly less than the 250-nm resolution of light microscopy. We regard the leukemia in these three patients as comprising a distinct clinical, ultrastructural, and cytogenetic entity that we have chosen to call "microgranular" acute promyelocytic leukemia.
通过透射电子显微镜发现，三名患有急性白血病、弥散性血管内凝血且伴有特定获得性染色体异常[t(15;17)]的患者，其早幼粒细胞中的颗粒具有典型分布。然而，这三名患者的颗粒平均大小分别为120纳米、170纳米和180纳米，明显小于光学显微镜250纳米的分辨率。我们认为这三名患者所患的白血病构成了一种独特的临床、超微结构和细胞遗传学实体，我们将其命名为“微颗粒型”急性早幼粒细胞白血病。
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