Dao T L, Chan P C
Environ Health Perspect. 1983 Apr;50:219-25. doi: 10.1289/ehp.8350219.
Hormones, particularly ovarian steroids and pituitary prolactin, promote mammary carcinogenesis in rats treated with a carcinogen. Hormones also play a critical role during the initiation process as demonstrated by mammary carcinogenesis in ovariectomized rats. A diet high in fat content, especially polyunsaturated fat, promotes mammary tumorigenesis when it is fed to carcinogen-treated rats for a prolonged period of time. Although a high fat diet is not essential for neoplastic transformation of the mammary cells, its effect on initiation is demonstrated when it is fed to rats for a long duration. Thus, both hormones and high dietary fat play a dual function in mammary carcinogenesis. There are indications that dietary fat may modulate endocrine activities, but a relationship between dietary fat and endocrine function remains to be conclusively demonstrated.
激素，尤其是卵巢类固醇和垂体催乳素，可促进经致癌物处理的大鼠发生乳腺癌。如去卵巢大鼠的乳腺癌发生情况所示，激素在起始过程中也起着关键作用。当长期给经致癌物处理的大鼠喂食高脂肪含量的饮食，尤其是多不饱和脂肪时，会促进乳腺肿瘤的发生。虽然高脂肪饮食对于乳腺细胞的肿瘤转化并非必不可少，但当长期喂给大鼠时，其对起始过程的影响是明显的。因此，激素和高膳食脂肪在乳腺癌发生过程中都发挥着双重作用。有迹象表明膳食脂肪可能会调节内分泌活动，但膳食脂肪与内分泌功能之间的关系仍有待确凿证明。
