Smeraldi E, Negri F, Melica A M, Scorza-Smeraldi R, Fabio G, Bonara P, Bellodi L, Sacchetti E, Sabbadini-Villa M G, Cazzullo C L, Zanussi C
Neuropsychobiology. 1978;4(6):344-52. doi: 10.1159/000117650.
HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and 50 bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.
对91名情感障碍患者的HLA表型分布进行了研究。发现HLA - A29和Bw22频率相较于对照人群显著增加，而A10和A30频率降低。两个临床亚组（41名单相情感障碍患者和50名双相情感障碍患者）之间未显示出显著差异。将我们的数据与其他作者的数据进行比较时，发现Bw16显著增加。然而，该抗原也显示出高度的异质性。有意思的是，长期锂盐治疗期间复发和未复发的患者表现出不同的HLA表型分布，未复发患者中B5增加。
