Shapiro R W, Ryder L P, Svejgaard A, Rafaelsen O J
Psychol Med. 1977 Aug;7(3):387-96. doi: 10.1017/s0033291700004359.
One hundred and seven unrelated Danish patients considered to be manic-depressive according to strict diagnostic, symptomatic and course criteria were typed for antigens of the HLA system, the major histocompatibility system in man. Preliminary results from the first 47 patients had previously been reported to suggest a positive association between manic-depressive disorders and HLA-A3, HLA-B7, and HLA-Bw16 and a negative association between such disorders and HLA-B8. Results from the extended series provide confirmatory evidence that there is a positive association between manic-depressive disorders and HLA-Bw16 and also strongly suggest a positive association between HLA-B7 and such disorders. HLA typing may prove to be a useful way of identifying sub-groups of manic-depressive patients for other biological studies. The associations described provide a potential lead for formulating hypotheses about the nature of the biological mechanisms which predispose to manic-depressive disorders.
按照严格的诊断、症状和病程标准，107名无亲缘关系的丹麦患者被诊断为躁郁症，并对人类主要组织相容性系统HLA系统的抗原进行了分型。此前已报道了前47名患者的初步结果，提示躁郁症与HLA - A3、HLA - B7和HLA - Bw16之间存在正相关，与HLA - B8之间存在负相关。扩大样本后的结果提供了确凿证据，表明躁郁症与HLA - Bw16之间存在正相关，也强烈提示HLA - B7与躁郁症之间存在正相关。HLA分型可能被证明是一种有用的方法，可为其他生物学研究识别躁郁症患者的亚组。所描述的相关性为阐述导致躁郁症的生物学机制的本质提供了潜在线索。
