软骨细胞黏附因子的鉴定
Identification of an adhesion factor for chondrocytes.
作者信息
Hewitt A T, Kleinman H K, Pennypacker J P, Martin G R
出版信息
Proc Natl Acad Sci U S A. 1980 Jan;77(1):385-8. doi: 10.1073/pnas.77.1.385.
Abstract
The attachment of chondrocytes to collagen substrates is stimulated by serum but not by fibronectin. The active material in serum was partially purified and was shown to be a protein by its sensitivity to trypsin and heat and its chromatographic properties. This factor, which we have named chondronectin, is distinct from fibronectin and does not stimulate fibroblast attachment. Because material with similar attachment-enhancing activity is produced by chondrocytes and is extractable from cartilage, chondronectin may be a chondrocyte-specific attachment protein.
摘要
血清可刺激软骨细胞附着于胶原蛋白底物，而纤连蛋白则无此作用。血清中的活性物质经部分纯化，因其对胰蛋白酶、热的敏感性及色谱特性表明该物质为一种蛋白质。我们将此因子命名为软骨粘连蛋白，它不同于纤连蛋白，且不刺激成纤维细胞附着。由于软骨细胞可产生具有类似附着增强活性的物质，且该物质可从软骨中提取，因此软骨粘连蛋白可能是一种软骨细胞特异性附着蛋白。
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