平滑肌细胞与胶原蛋白的附着及其向血小板衍生生长因子的迁移。
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.
作者信息
Grotendorst G R, Seppä H E, Kleinman H K, Martin G R
出版信息
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72. doi: 10.1073/pnas.78.6.3669.
Abstract
Smooth muscle cells use fibronectin to bind to type I and type III collagens but bind to type V collagen by a trypsin-resistant intrinsic glycoconjugate. The binding site on type V collagen is located in the alpha A chain. By using collagen-coated filters in a modified Boyden chamber assay for chemotaxis, it was observed that the platelet-derived growth factor was chemotactic for smooth muscle cells but that several other growth factors were inactive. We suggest that the migration of smooth muscle cells from the media to the intima of a blood vessel, which leads to the formation of an atherosclerotic plaque, may be the result of a chemotactic migration of cells responsive to the platelet-derived growth factor.
摘要
平滑肌细胞利用纤连蛋白与I型和III型胶原结合，但通过一种抗胰蛋白酶的内在糖缀合物与V型胶原结合。V型胶原上的结合位点位于αA链中。通过在改良的博伊登室趋化性分析中使用胶原包被的滤膜，观察到血小板衍生生长因子对平滑肌细胞具有趋化作用，而其他几种生长因子则无活性。我们认为，平滑肌细胞从血管中膜迁移至内膜并导致动脉粥样硬化斑块形成，可能是细胞对血小板衍生生长因子产生趋化性迁移的结果。
相似文献
1
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.平滑肌细胞与胶原蛋白的附着及其向血小板衍生生长因子的迁移。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72. doi: 10.1073/pnas.78.6.3669.
2
3
Apolipoprotein J inhibits the migration, adhesion, and proliferation of vascular smooth muscle cells.载脂蛋白J抑制血管平滑肌细胞的迁移、黏附和增殖。
J Vasc Surg. 2001 Oct;34(4):716-23. doi: 10.1067/mva.2001.116301.
4
A platelet-derived factor chemotactic for rabbit arterial smooth muscle cells in culture.
Artery. 1981;9(4):316-27.
5
Substratum-bound elastin peptide inhibits aortic smooth muscle cell migration in vitro.
Arteriosclerosis. 1987 Nov-Dec;7(6):593-8. doi: 10.1161/01.atv.7.6.593.
6
Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells.血小板衍生生长因子是血管平滑肌细胞的一种化学引诱剂。
J Cell Physiol. 1982 Nov;113(2):261-6. doi: 10.1002/jcp.1041130213.
7
Polyamines and atherosclerosis. Platelet releasate and other mitogens stimulate putrescine transport in arterial smooth muscle cells.
Atherosclerosis. 1982 Jul;44(1):49-60. doi: 10.1016/0021-9150(82)90052-1.
8
Platelet-derived growth factor in chemotactic for fibroblasts.血小板衍生生长因子对成纤维细胞具有趋化作用。
J Cell Biol. 1982 Feb;92(2):584-8. doi: 10.1083/jcb.92.2.584.
9
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.胰岛素样生长因子-I和血小板衍生生长因子-BB通过与增殖信号通路不同的信号通路诱导人动脉平滑肌细胞定向迁移。
J Clin Invest. 1994 Mar;93(3):1266-74. doi: 10.1172/JCI117081.
10
Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen.
Biochem Soc Trans. 2002 Apr;30(2):102-11.
引用本文的文献
1
Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish.血小板衍生生长因子A链/血小板衍生生长因子受体α介导的化学吸引引导斑马鱼中胚层体节来源的成纤维细胞前体的迁移。
PLoS Biol. 2025 Sep 2;23(9):e3003365. doi: 10.1371/journal.pbio.3003365. eCollection 2025 Sep.
2
Development of Growth Factor Releasing Hyaluronic Acid-Based Hydrogel for Pulp Regeneration: A Preliminary Study.用于牙髓再生的生长因子释放透明质酸基水凝胶的开发：一项初步研究。
Gels. 2022 Dec 13;8(12):825. doi: 10.3390/gels8120825.
3
Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.癌症进展中集体细胞迁移的生物力学：实验与计算方法
ACS Biomater Sci Eng. 2019;5(8):3766-3787. doi: 10.1021/acsbiomaterials.8b01428. Epub 2019 May 22.
4
Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery.芳香烃受体核转位蛋白在血管平滑肌细胞中对于最佳外周灌注恢复是必需的。
J Am Heart Assoc. 2018 Jun 1;7(11):e009205. doi: 10.1161/JAHA.118.009205.
5
Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling.衰老通过适应性细胞外基质重塑对压力超负荷心肌病具有保护作用。
Am J Cardiovasc Dis. 2017 Jun 15;7(3):72-82. eCollection 2017.
6
The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.骨髓细胞源性血小板衍生生长因子-B在组织工程血管移植物新组织形成中的作用。
Regen Med. 2017 Apr;12(3):249-261. doi: 10.2217/rme-2016-0141. Epub 2017 May 19.
7
Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate.烟酸占替诺对人脐动脉平滑肌细胞增殖的抑制作用
Med Biol Eng Comput. 2016 Jun;54(6):891-8. doi: 10.1007/s11517-015-1438-9. Epub 2015 Dec 30.
8
A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration.一种无管道微流控伤口愈合分析方法，可实现血管平滑肌细胞迁移的定量分析。
Sci Rep. 2015 Sep 14;5:14049. doi: 10.1038/srep14049.
9
Terminalia chebula Fructus Inhibits Migration and Proliferation of Vascular Smooth Muscle Cells and Production of Inflammatory Mediators in RAW 264.7.诃子果实抑制 RAW 264.7 血管平滑肌细胞的迁移和增殖及炎症介质的产生。
Evid Based Complement Alternat Med. 2015;2015:502182. doi: 10.1155/2015/502182. Epub 2015 Feb 16.
10
Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia.肺动脉平滑肌细胞内皮素-1的表达调节肺血管对慢性缺氧的反应。
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L368-77. doi: 10.1152/ajplung.00253.2014. Epub 2014 Nov 14.
本文引用的文献
1
Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen.层粘连蛋白在PAM 212（上皮）细胞与基底膜胶原蛋白附着中的作用。
Cell. 1980 Dec;22(3):719-26. doi: 10.1016/0092-8674(80)90548-6.
2
Role of attachment factors and attractants in fibroblast chemotaxis.黏附因子和趋化剂在成纤维细胞趋化性中的作用。
J Lab Clin Med. 1980 Dec;96(6):1071-80.
3
Fibronectin-collagen binding and requirement during cellular adhesion.细胞黏附过程中纤连蛋白与胶原蛋白的结合及需求
Biochem J. 1980 Feb 15;186(2):551-9. doi: 10.1042/bj1860551.
4
Collagen molecules comprised of alpha 1(V)-chains (B-chains): an apparent localization in the exocytoskeleton.由α1（V）链（B链）组成的胶原蛋白分子：在外细胞骨架中的明显定位。
Coll Relat Res. 1981;1(1):53-8. doi: 10.1016/s0174-173x(80)80007-0.
5
The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta.正常和动脉粥样硬化的人类主动脉中I型、III型和V型（AB）胶原蛋白的分布。
J Pathol. 1980 Jan;130(1):45-55. doi: 10.1002/path.1711300107.
6
Identification of an adhesion factor for chondrocytes.软骨细胞黏附因子的鉴定
Proc Natl Acad Sci U S A. 1980 Jan;77(1):385-8. doi: 10.1073/pnas.77.1.385.
7
The nature of the intramolecular cross-links in collagen. The separation and characterization of peptides from the cross-link region of rat skin collagen.胶原蛋白分子内交联的性质。大鼠皮肤胶原蛋白交联区域肽段的分离与鉴定。
Biochemistry. 1966 Nov;5(11):3460-73. doi: 10.1021/bi00875a012.
8
Synthesis of soluble elastin by aortic medial cells in culture.
Biochem Biophys Res Commun. 1974 Jun 4;58(3):597-604. doi: 10.1016/s0006-291x(74)80461-4.
9
Dissociation of cell division stimulating capacity for Balb-c-3T3 from the insulin-like activity in human serum.
Nature. 1974 Feb 1;247(5439):279-81. doi: 10.1038/247279a0.
10
Use of genetic markers to study cellular origin and development of tumors in human females.
Adv Cancer Res. 1972;15:191-226. doi: 10.1016/s0065-230x(08)60375-9.
Zotero 插件