小鼠中Sts基因的剂量
Dosage of the Sts gene in the mouse.
作者信息
Keitges E, Gartler S M
出版信息
Am J Hum Genet. 1986 Oct;39(4):470-6.
Abstract
In this study we compared steroid sulfatase levels in XO, XX, and XY mice and carried out a clonal analysis in fibroblast cell cultures from mice heterozygous for the steroid sulfatase deficiency gene and heterozygous at the X-linked electrophoretic phosphoglycerate kinase locus. The combined results indicate that the murine steroid sulfatase locus is not dosage compensated and is not subject to X-inactivation. With respect to X-inactivation, it behaves in a somewhat different way from the closely linked sex-reversed gene and the human steroid sulfatase locus.
摘要
在本研究中，我们比较了XO、XX和XY小鼠的类固醇硫酸酯酶水平，并对类固醇硫酸酯酶缺陷基因杂合且X连锁电泳磷酸甘油酸激酶位点杂合的小鼠成纤维细胞培养物进行了克隆分析。综合结果表明，小鼠类固醇硫酸酯酶基因座没有剂量补偿，也不受X染色体失活的影响。关于X染色体失活，它的行为方式与紧密连锁的性反转基因和人类类固醇硫酸酯酶基因座略有不同。
相似文献
1
Dosage of the Sts gene in the mouse.小鼠中Sts基因的剂量
Am J Hum Genet. 1986 Oct;39(4):470-6.
2
Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice.小鼠中类固醇硫酸酯酶X连锁的证据：XX和XO小鼠卵母细胞中的类固醇硫酸酯酶水平。
Genetics. 1983 Jan;103(1):137-41. doi: 10.1093/genetics/103.1.137.
3
X-linked steroid sulfatase: evidence for different gene-dosage in males and females.X连锁类固醇硫酸酯酶：男性和女性基因剂量差异的证据。
Hum Genet. 1980;54(2):197-9. doi: 10.1007/BF00278971.
4
Evidence for a dosage effect at the X-linked steroid sulfatase locus in human tissues.人类组织中X连锁类固醇硫酸酯酶基因座存在剂量效应的证据。
Am J Hum Genet. 1983 Mar;35(2):234-40.
5
X-inactivation of the Sts locus in the mouse: an anomaly of the dosage compensation mechanism.
Genet Res. 1989 Jun;53(3):193-9. doi: 10.1017/s0016672300028160.
6
Steroid sulphatase levels are higher in males than in females of the root vole (Microtus oeconomus). Yet another rodent with an active Y-linked allele?根田鼠（Microtus oeconomus）雄性个体中的类固醇硫酸酯酶水平高于雌性。它会是另一种具有活跃的Y连锁等位基因的啮齿动物吗？
Hum Genet. 1987 Sep;77(1):6-11. doi: 10.1007/BF00284705.
7
Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations.具有数目和结构X染色体畸变的成纤维细胞中类固醇硫酸酯酶的活性。
Hum Genet. 1981;57(4):354-6. doi: 10.1007/BF00281683.
8
Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.类固醇硫酸酯酶基因与小鼠性反转突变的连锁关系。
Genetics. 1987 Jul;116(3):465-8. doi: 10.1093/genetics/116.3.465.
9
Steroid sulphatase in man: a non inactivated X-locus with partial gene dosage compensation.人类类固醇硫酸酯酶：一个具有部分基因剂量补偿的未失活X位点。
Hum Genet. 1984;65(4):355-7. doi: 10.1007/BF00291559.
10
Evidence for x-linkage and non-inactivation of steroid sulphatase locus in wood lemming.关于林地旅鼠中类固醇硫酸酯酶基因座的X连锁和非失活的证据。
Nature. 1982 Apr 22;296(5859):766-7. doi: 10.1038/296766a0.
引用本文的文献
1
Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.对小鼠 X 染色体剂量的转录反应变化：对 X 染色体失活和特纳综合征分子基础的影响。
BMC Genomics. 2010 Feb 1;11:82. doi: 10.1186/1471-2164-11-82.
2
Isolation and characterization of a pseudoautosomal region-specific genetic marker in C57BL/6 mice using genomic representational difference analysis.利用基因组代表性差异分析分离和鉴定C57BL/6小鼠假常染色体区域特异性遗传标记
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12352-6. doi: 10.1073/pnas.92.26.12352.
3
Linkage of the murine steroid sulfatase locus, Sts, to sex reversed, Sxr: a genetic and molecular analysis.小鼠类固醇硫酸酯酶基因座（Sts）与性反转基因Sxr的连锁：一项遗传与分子分析
Nucleic Acids Res. 1987 Nov 25;15(22):9227-38. doi: 10.1093/nar/15.22.9227.
4
Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.类固醇硫酸酯酶基因与小鼠性反转突变的连锁关系。
Genetics. 1987 Jul;116(3):465-8. doi: 10.1093/genetics/116.3.465.
5
Steroid sulphatase levels are higher in males than in females of the root vole (Microtus oeconomus). Yet another rodent with an active Y-linked allele?根田鼠（Microtus oeconomus）雄性个体中的类固醇硫酸酯酶水平高于雌性。它会是另一种具有活跃的Y连锁等位基因的啮齿动物吗？
Hum Genet. 1987 Sep;77(1):6-11. doi: 10.1007/BF00284705.
6
Y chromosome and aggression in strains of laboratory mice.Y染色体与实验小鼠品系中的攻击性
Behav Genet. 1990 Jan;20(1):137-56. doi: 10.1007/BF01070750.
7
Inactivation of the Zfx gene on the mouse X chromosome.小鼠X染色体上Zfx基因的失活。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4592-5. doi: 10.1073/pnas.88.11.4592.
本文引用的文献
1
Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse.X 染色体连锁磷酸甘油酸激酶（pgk-1）在小鼠中的电泳变异。
Genetics. 1977 Oct;87(2):319-25. doi: 10.1093/genetics/87.2.319.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
A human quantitative polymorphism related to Xg blood groups.一种与Xg血型相关的人类数量多态性。
Nature. 1981 Jan 29;289(5796):404-5. doi: 10.1038/289404a0.
4
Fertile females produced by inactivation of an X chromosome of "sex-reversed' mice.
Nature. 1982 Dec 2;300(5891):446-8. doi: 10.1038/300446a0.
5
Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the x and an aberrant y chromosome.小鼠（小家鼠）的性反转是由涉及X染色体和一条异常Y染色体的反复发生的非相互交叉所引起的。
Cell. 1982 Feb;28(2):205-16. doi: 10.1016/0092-8674(82)90338-5.
6
Regional assignment of the gene locus for steroid sulfatase.类固醇硫酸酯酶基因位点的区域定位
Hum Genet. 1980;54(2):201-4. doi: 10.1007/BF00278972.
7
Male, female and intersex development in mice of identical chromosome constitution.
Nature. 1982 Dec 2;300(5891):445-6. doi: 10.1038/300445a0.
8
Differential expression of steroid sulphatase locus on active and inactive human X chromosome.类固醇硫酸酯酶基因座在人类活性和失活X染色体上的差异表达。
Nature. 1982 Oct 28;299(5886):838-40. doi: 10.1038/299838a0.
9
Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations.具有数目和结构X染色体畸变的成纤维细胞中类固醇硫酸酯酶的活性。
Hum Genet. 1981;57(4):354-6. doi: 10.1007/BF00281683.
10
Expression of an X-linked gene from an inactive human X chromosome in mouse-human hybrid cells: further evidence for the noninactivation of the steroid sulfatase locus in man.人类X染色体失活状态下X连锁基因在人-鼠杂交细胞中的表达：关于人类类固醇硫酸酯酶基因座未失活的进一步证据
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6759-63. doi: 10.1073/pnas.77.11.6759.
Zotero 插件