Minami Y, Ohuchi N, Taeda Y, Takano A, Fukao A, Satomi S, Hisamichi S
Division of Epidemiology, Miyagi Cancer Center Research Institute, Natori.
Jpn J Cancer Res. 1999 Jun;90(6):600-6. doi: 10.1111/j.1349-7006.1999.tb00789.x.
To investigate the risk of breast cancer development in women with benign breast disease (BBD), 387 screen-detected BBD women and 1,489 normal women, taken from participants in the breast cancer screening program during 1978-1986, were followed through 1991. While 2,811 person-years in the BBD group and 11,018 person-years in the normal group were accumulated, 5 women in the BBD group and 6 women in the normal group developed breast cancer. Using the Mantel-Haenszel method, relative risks (RR) were estimated for all women with BBD and women in some BBD types. Significantly elevated risk of breast cancer was observed in all women with BBD (RR = 3.26, 95% confidence interval (CI) 1.08-9.83). Women with proliferative BBD were at high risk of breast cancer (RR = 8.48, 95% CI 2.99-24.10), but no increased risk was observed for women with non-proliferative BBD (RR = 0.93, 95% CI 0.11-7.66). These results are consistent with those in high-risk countries for breast cancer. In the management of women with BBD, histopathological diagnosis of the breast lesion is essential and women with proliferative BBD should be followed up carefully.
为了调查患有良性乳腺疾病（BBD）的女性患乳腺癌的风险，选取了1978年至1986年期间参加乳腺癌筛查项目的387名经筛查发现患有BBD的女性和1489名正常女性，随访至1991年。在BBD组累积了2811人年，正常组累积了11018人年，BBD组有5名女性患乳腺癌，正常组有6名女性患乳腺癌。使用Mantel-Haenszel方法，估计了所有患有BBD的女性以及某些BBD类型女性的相对风险（RR）。在所有患有BBD的女性中观察到乳腺癌风险显著升高（RR = 3.26，95%置信区间（CI）1.08 - 9.83）。患有增殖性BBD的女性患乳腺癌风险高（RR = 8.48，95%CI 2.99 - 24.10），但未观察到非增殖性BBD女性的风险增加（RR = 0.93，95%CI 0.11 - 7.66）。这些结果与乳腺癌高风险国家的结果一致。在BBD女性的管理中，乳腺病变的组织病理学诊断至关重要，患有增殖性BBD的女性应仔细随访。
