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Structure of a mycobacterial polysaccharide-fatty acyl-CoA complex: nuclear magnetic resonance studies.一种分枝杆菌多糖-脂肪酰辅酶A复合物的结构：核磁共振研究
Proc Natl Acad Sci U S A. 1980 May;77(5):2582-6. doi: 10.1073/pnas.77.5.2582.
2
Complex formation between mycobacterial polysaccharides or cyclodextrins and palmitoyl coenzyme A.分枝杆菌多糖或环糊精与棕榈酰辅酶A之间的复合物形成。
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Interaction of mycobacterial polymethylpolysaccharides with paranaric acid and palmitoyl-coenzyme A: structural specificity and monomeric dissociation constants.分枝杆菌聚甲基多糖与副蓖麻酸和棕榈酰辅酶A的相互作用：结构特异性和单体解离常数
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Mycobacterium smegmatis fatty acid synthetase. A mechanism based on steady state rates and product distributions.耻垢分枝杆菌脂肪酸合成酶。基于稳态速率和产物分布的机制。
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Conformational changes associated with complex formation between a mycobacterial polymethylpolysaccharide and palmitic acid.分枝杆菌聚甲基多糖与棕榈酸形成复合物时伴随的构象变化。
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6
Complex formation between mycobacterial polysaccharides and fatty acyl-CoA derivatives.分枝杆菌多糖与脂肪酰辅酶A衍生物之间的复合物形成。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1146-8. doi: 10.1073/pnas.70.4.1146.
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9
Reversible inhibition of the fatty acid synthetase complex from Mycobacterium smegmatis by palmitoyl-coenzyme A.棕榈酰辅酶A对耻垢分枝杆菌脂肪酸合成酶复合物的可逆抑制作用。
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10
Affinity purification of mycobacterial polymethyl polysaccharides and a study of polysaccharide-lipid interactions by 1H NMR.分枝杆菌聚甲基多糖的亲和纯化及通过核磁共振氢谱对多糖-脂质相互作用的研究
Biochemistry. 1984 Jan 31;23(3):577-84. doi: 10.1021/bi00298a028.

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1
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides.分枝杆菌甲基甘露聚糖的生物合成需要一种独特的 1--甲基转移酶，该酶特异性识别 3--甲基化的甘露糖苷。
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):835-844. doi: 10.1073/pnas.1813450116. Epub 2019 Jan 3.
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ACS Chem Biol. 2012 Jan 20;7(1):31-43. doi: 10.1021/cb2004466. Epub 2012 Jan 11.
3
Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.第2章：结核分枝杆菌细胞壁及其他糖缀合物的生物合成
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Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.吡嗪酰胺对完整分枝杆菌细胞及纯化的脂肪酸合酶I合成脂肪酸的影响。
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本文引用的文献

1
3-O-methyl-D-mannose from Streptomyces griseus.来自灰色链霉菌的3-O-甲基-D-甘露糖。
Biochem J. 1966 Jan;98(1):15-8. doi: 10.1042/bj0980015.
2
Synthesis of fatty acyl CoA and other thiol esters using N-hydroxysuccinimide esters of fatty acids.使用脂肪酸的N-羟基琥珀酰亚胺酯合成脂肪酰辅酶A和其他硫醇酯。
J Lipid Res. 1969 May;10(3):344-5.
3
Some physical properties of palmityl-coenzyme A micelles.棕榈酰辅酶A胶束的一些物理性质。
Biochim Biophys Acta. 1968 Sep 2;164(1):1-11. doi: 10.1016/0005-2760(68)90065-9.
4
The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Structure of the reducing end of the polysaccharide.草分枝杆菌含6-O-甲基葡萄糖的脂多糖。多糖还原端的结构。
J Biol Chem. 1968 Aug 25;243(16):4319-31.
5
Fatty acid synthetase activity in Mycobacterium phlei: regulation by polysaccharides.草分枝杆菌中的脂肪酸合成酶活性：多糖的调节作用
Proc Natl Acad Sci U S A. 1971 Jan;68(1):87-91. doi: 10.1073/pnas.68.1.87.
6
Isolation and characterization of a polysaccharide containing 3-O-methyl-D-mannose from Mycobacterium phlei.从草分枝杆菌中分离并鉴定一种含3-O-甲基-D-甘露糖的多糖。
J Biol Chem. 1971 Nov 25;246(22):6835-42.
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Helix-coil transition of a synthetic polypeptide monitored by fourier transform carbon-13 nuclear magnetic resonance.通过傅里叶变换碳-13核磁共振监测合成多肽的螺旋-卷曲转变。
J Am Chem Soc. 1972 May 17;94(10):3639-41. doi: 10.1021/ja00765a070.
8
Vitro alterations of the product distribution of the fatty synthetase from Mycobacterium phlei.草分枝杆菌脂肪酸合成酶产物分布的体外改变。
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9
The 6-O-methylglucose-containing lipopolysaccharides of Mycobacterium phlei. Locations of the neutral and acidic acyl groups.草分枝杆菌含6-O-甲基葡萄糖的脂多糖。中性和酸性酰基的位置。
J Biol Chem. 1973 Oct 25;248(20):7118-25.
10
Determination of rotational mobilities of backbone and side-chain carbons of poly(gamma-benzyl L-glutamate) in the helical and random-coil states from measurements of carbon-13 relaxation times and nuclear Overhauser enhancements.通过碳-13弛豫时间和核Overhauser增强测量确定聚（γ-苄基-L-谷氨酸）在螺旋态和无规卷曲态下主链和侧链碳的旋转迁移率。
Biochemistry. 1973 Aug 28;12(18):3428-33. doi: 10.1021/bi00742a011.

一种分枝杆菌多糖-脂肪酰辅酶A复合物的结构：核磁共振研究

Structure of a mycobacterial polysaccharide-fatty acyl-CoA complex: nuclear magnetic resonance studies.

作者信息

Maggio J E

出版信息

Proc Natl Acad Sci U S A. 1980 May;77(5):2582-6. doi: 10.1073/pnas.77.5.2582.

DOI:10.1073/pnas.77.5.2582
PMID:6930653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC349446/
Abstract

MMP, a linear alpha 1 leads to 4 linked polymer of 3-O-methylmannose, regulates the fatty acid synthetase from Mycobacterium smegmatis by forming stoichiometric complexes with the long-chain acyl-CoA synthetase products. In agreement with previous proposals [Bloch, K. (1977) in Advances in Enzymology and Related Areas of Molecular Biology, ed. Meister, A. (Wiley, New York), Vol. 45, pp. 1-84], nuclear magnetic resonance studies show that the polysaccharide, a random coil in its free form, undergoes a major conformational transition upon enclosing long-chain acyl-CoA. The polysaccharide, probably in helical conformation in the complexed form, interacts with both the paraffinic chain and the CoA moieties of the included fatty acyl thioester.

摘要

MMP是一种由3 - O - 甲基甘露糖构成的线性α1至4连接的聚合物，它通过与长链酰基辅酶A合成酶产物形成化学计量复合物来调节耻垢分枝杆菌的脂肪酸合成酶。与之前的提议一致[布洛赫，K.（1977年），载于《酶学及分子生物学相关领域进展》，编者迈斯特，A.（威利出版社，纽约），第45卷，第1 - 84页]，核磁共振研究表明，多糖在其自由形式下是无规卷曲，在包裹长链酰基辅酶A时会发生主要的构象转变。该多糖在复合形式下可能呈螺旋构象，与所含脂肪酰硫酯的石蜡链和辅酶A部分相互作用。