Al-Nakeeb S, Thompson E N
Arch Dis Child. 1980 Apr;55(4):299-303. doi: 10.1136/adc.55.4.299.
The cellular and humoral components of the neutrophil chemotactic response were studied in 65 children with acute lymphoblastic leukaemia (ALL). An abnormality in both components was found during relapse. In remission the cellular component only was affected. Although less obvious than during relapse the abnormality persisted while all cytotoxic therapy was given, returning to normal several weeks after treatment had been stopped. The absence of significant infection in relapse in this series could be due to the fact that a remisison was achieved within 3 weeks in all patients. However, a positive correlation between the migration index and incidence of bacterial infection during remission stressed the importance of impaired neutrophil chemotaxis in ALL.
对65例急性淋巴细胞白血病（ALL）患儿的中性粒细胞趋化反应的细胞和体液成分进行了研究。在复发期间发现两种成分均异常。在缓解期，仅细胞成分受到影响。虽然不如复发时明显，但在进行所有细胞毒性治疗期间，异常情况持续存在，在治疗停止数周后恢复正常。该系列中复发时无明显感染可能是由于所有患者均在3周内实现缓解。然而，缓解期迁移指数与细菌感染发生率之间的正相关强调了ALL中中性粒细胞趋化受损的重要性。
